Retinoblastoma Tumorigenesis

Michael A. Dyer, Michael A. Dyer, J. William Harbour, J. William Harbour, J. William Harbour

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tumorigenesis is a multistep process that involves sequential genetic alterations [1]. Preneoplastic cells must overcome their dependence on extrinsic mitogenic signals, evade apoptosis, prevent degradation of life-span-limiting telomeres, recruit vasculature, and acquire invasive properties to become malignant tumor cells [1].

Original languageEnglish (US)
Title of host publicationClinical Ophthalmic Oncology: Retinoblastoma, Second Edition
PublisherSpringer Berlin Heidelberg
Pages61-68
Number of pages8
ISBN (Print)9783662434512, 9783662434505
DOIs
StatePublished - Jan 1 2015

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dyer, M. A., Dyer, M. A., William Harbour, J., Harbour, J. W., & Harbour, J. W. (2015). Retinoblastoma Tumorigenesis. In Clinical Ophthalmic Oncology: Retinoblastoma, Second Edition (pp. 61-68). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-43451-2_6