Retinoblastoma: Clinical and molecular perspectives

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Retinoblastoma is a rare eye cancer that has been fundamental to the understanding of tumorigenesis. The RB gene was the first tumor suppressor gene to be discovered, and the Rb protein is targeted for inactivation in the vast majority of human cancers. This chapter reviews the clinical features of retinoblastoma and highlights the insights into molecular oncology that have resulted from study of the Rb tumor suppressor pathway.

Original languageEnglish (US)
Title of host publicationThe Molecular Basis of Human Cancer
PublisherSpringer New York
Pages355-361
Number of pages7
ISBN (Electronic)9781597454582
ISBN (Print)9781934115183
DOIs
StatePublished - Jan 1 2016

Keywords

  • Apoptosis
  • Cell cycle
  • Differentiation
  • Eye cancer
  • Retinoblastoma
  • Tumor suppressor

ASJC Scopus subject areas

  • Medicine(all)

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