Retinal microvasculature alteration in high Myopia

Ye Yang, Jianhua Wang, Hong Jiang, Xiaoling Yang, Limiao Feng, Liang Hu, Liang Wang, Fan Lu, Meixiao Shen

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

PURPOSE. To investigate the retinal vascular network alterations in highly myopic eyes. METHODS. Thirty-three highly myopic eyes from 21 subjects and 47 mildly myopic or emmetropic eyes from 24 healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) was used to image the superficial, deep, and whole retinal vascular plexuses at the macular region. Highly myopic eye images were analyzed after adjusting the ocular magnification using Bennett’s formula. Fractal analysis (box counting method, Dbox) representing vessel density was performed in different annular and quadrantile zones of both large vessels and microvessels. Correlations between the vascular density, axial length, and spherical equivalent refractive error were analyzed. RESULTS. The average density (Dbox) of the superficial retinal annular zone (0.6–2.5 mm) microvessels was 1.741 ± 0.018 in highly myopic eyes and was shown to be significantly lower than that of the controls (1.773 ± 0.010, P < 0.001). Individual annular zone (bandwidth of 0.16 mm) analysis of highly myopic eyes revealed a significant level of microvessel alteration in all zones compared with the same zones in control eyes (P < 0.001). Furthermore, in the highly myopic group, the microvessel density was significantly correlated with axial length elongation in all three layers (r = -0.38 to -0.48; P < 0.05). CONCLUSIONS. This study reveals retinal microvascular network alterations in highly myopic eyes, which correlates with axial length elongation. Fractal analysis of the microvasculature by OCTA images may help to characterize the underlying pathophysiological mechanisms involved in high myopia.

Original languageEnglish (US)
Pages (from-to)6020-6030
Number of pages11
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number14
DOIs
StatePublished - Nov 1 2016

Fingerprint

Myopia
Microvessels
Retinal Vessels
Fractals
Optical Coherence Tomography
Angiography
Refractive Errors
Blood Vessels
Healthy Volunteers

Keywords

  • Fractal analysis
  • High myopia
  • Microvasculature
  • Optical coherence tomography angiography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Retinal microvasculature alteration in high Myopia. / Yang, Ye; Wang, Jianhua; Jiang, Hong; Yang, Xiaoling; Feng, Limiao; Hu, Liang; Wang, Liang; Lu, Fan; Shen, Meixiao.

In: Investigative Ophthalmology and Visual Science, Vol. 57, No. 14, 01.11.2016, p. 6020-6030.

Research output: Contribution to journalArticle

Yang, Y, Wang, J, Jiang, H, Yang, X, Feng, L, Hu, L, Wang, L, Lu, F & Shen, M 2016, 'Retinal microvasculature alteration in high Myopia', Investigative Ophthalmology and Visual Science, vol. 57, no. 14, pp. 6020-6030. https://doi.org/10.1167/iovs.16-19542
Yang, Ye ; Wang, Jianhua ; Jiang, Hong ; Yang, Xiaoling ; Feng, Limiao ; Hu, Liang ; Wang, Liang ; Lu, Fan ; Shen, Meixiao. / Retinal microvasculature alteration in high Myopia. In: Investigative Ophthalmology and Visual Science. 2016 ; Vol. 57, No. 14. pp. 6020-6030.
@article{24f2b480fd6849baa515db1f42f6d096,
title = "Retinal microvasculature alteration in high Myopia",
abstract = "PURPOSE. To investigate the retinal vascular network alterations in highly myopic eyes. METHODS. Thirty-three highly myopic eyes from 21 subjects and 47 mildly myopic or emmetropic eyes from 24 healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) was used to image the superficial, deep, and whole retinal vascular plexuses at the macular region. Highly myopic eye images were analyzed after adjusting the ocular magnification using Bennett’s formula. Fractal analysis (box counting method, Dbox) representing vessel density was performed in different annular and quadrantile zones of both large vessels and microvessels. Correlations between the vascular density, axial length, and spherical equivalent refractive error were analyzed. RESULTS. The average density (Dbox) of the superficial retinal annular zone (0.6–2.5 mm) microvessels was 1.741 ± 0.018 in highly myopic eyes and was shown to be significantly lower than that of the controls (1.773 ± 0.010, P < 0.001). Individual annular zone (bandwidth of 0.16 mm) analysis of highly myopic eyes revealed a significant level of microvessel alteration in all zones compared with the same zones in control eyes (P < 0.001). Furthermore, in the highly myopic group, the microvessel density was significantly correlated with axial length elongation in all three layers (r = -0.38 to -0.48; P < 0.05). CONCLUSIONS. This study reveals retinal microvascular network alterations in highly myopic eyes, which correlates with axial length elongation. Fractal analysis of the microvasculature by OCTA images may help to characterize the underlying pathophysiological mechanisms involved in high myopia.",
keywords = "Fractal analysis, High myopia, Microvasculature, Optical coherence tomography angiography",
author = "Ye Yang and Jianhua Wang and Hong Jiang and Xiaoling Yang and Limiao Feng and Liang Hu and Liang Wang and Fan Lu and Meixiao Shen",
year = "2016",
month = "11",
day = "1",
doi = "10.1167/iovs.16-19542",
language = "English (US)",
volume = "57",
pages = "6020--6030",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "14",

}

TY - JOUR

T1 - Retinal microvasculature alteration in high Myopia

AU - Yang, Ye

AU - Wang, Jianhua

AU - Jiang, Hong

AU - Yang, Xiaoling

AU - Feng, Limiao

AU - Hu, Liang

AU - Wang, Liang

AU - Lu, Fan

AU - Shen, Meixiao

PY - 2016/11/1

Y1 - 2016/11/1

N2 - PURPOSE. To investigate the retinal vascular network alterations in highly myopic eyes. METHODS. Thirty-three highly myopic eyes from 21 subjects and 47 mildly myopic or emmetropic eyes from 24 healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) was used to image the superficial, deep, and whole retinal vascular plexuses at the macular region. Highly myopic eye images were analyzed after adjusting the ocular magnification using Bennett’s formula. Fractal analysis (box counting method, Dbox) representing vessel density was performed in different annular and quadrantile zones of both large vessels and microvessels. Correlations between the vascular density, axial length, and spherical equivalent refractive error were analyzed. RESULTS. The average density (Dbox) of the superficial retinal annular zone (0.6–2.5 mm) microvessels was 1.741 ± 0.018 in highly myopic eyes and was shown to be significantly lower than that of the controls (1.773 ± 0.010, P < 0.001). Individual annular zone (bandwidth of 0.16 mm) analysis of highly myopic eyes revealed a significant level of microvessel alteration in all zones compared with the same zones in control eyes (P < 0.001). Furthermore, in the highly myopic group, the microvessel density was significantly correlated with axial length elongation in all three layers (r = -0.38 to -0.48; P < 0.05). CONCLUSIONS. This study reveals retinal microvascular network alterations in highly myopic eyes, which correlates with axial length elongation. Fractal analysis of the microvasculature by OCTA images may help to characterize the underlying pathophysiological mechanisms involved in high myopia.

AB - PURPOSE. To investigate the retinal vascular network alterations in highly myopic eyes. METHODS. Thirty-three highly myopic eyes from 21 subjects and 47 mildly myopic or emmetropic eyes from 24 healthy control subjects were enrolled. Optical coherence tomography angiography (OCTA) was used to image the superficial, deep, and whole retinal vascular plexuses at the macular region. Highly myopic eye images were analyzed after adjusting the ocular magnification using Bennett’s formula. Fractal analysis (box counting method, Dbox) representing vessel density was performed in different annular and quadrantile zones of both large vessels and microvessels. Correlations between the vascular density, axial length, and spherical equivalent refractive error were analyzed. RESULTS. The average density (Dbox) of the superficial retinal annular zone (0.6–2.5 mm) microvessels was 1.741 ± 0.018 in highly myopic eyes and was shown to be significantly lower than that of the controls (1.773 ± 0.010, P < 0.001). Individual annular zone (bandwidth of 0.16 mm) analysis of highly myopic eyes revealed a significant level of microvessel alteration in all zones compared with the same zones in control eyes (P < 0.001). Furthermore, in the highly myopic group, the microvessel density was significantly correlated with axial length elongation in all three layers (r = -0.38 to -0.48; P < 0.05). CONCLUSIONS. This study reveals retinal microvascular network alterations in highly myopic eyes, which correlates with axial length elongation. Fractal analysis of the microvasculature by OCTA images may help to characterize the underlying pathophysiological mechanisms involved in high myopia.

KW - Fractal analysis

KW - High myopia

KW - Microvasculature

KW - Optical coherence tomography angiography

UR - http://www.scopus.com/inward/record.url?scp=84994756716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994756716&partnerID=8YFLogxK

U2 - 10.1167/iovs.16-19542

DO - 10.1167/iovs.16-19542

M3 - Article

C2 - 27820633

AN - SCOPUS:84994756716

VL - 57

SP - 6020

EP - 6030

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 14

ER -