TY - JOUR
T1 - Retinal microvascular impairment in the early stages of Parkinson’s disease
AU - Kwapong, William Robert
AU - Ye, Hua
AU - Peng, Chenlei
AU - Zhuang, Xiran
AU - Wang, Jianhua
AU - Shen, Meixiao
AU - Lu, Fan
N1 - Funding Information:
Supported by research grants from the National Nature Science Foundation of China (Grant Nos. 81570880 and11675122), the National Key Research and Development Program of China (2016YFE0107000, 2016YFC0102500), 111 Project (D16011), Zhejiang Provincial Natural Science Foundation of China (Grant No. LY16H160047), and Public Service Program of Wenzhou Science and Technology Bureau (Y20160151).
Funding Information:
Supported by research grants from the National Nature Science Foundation of China (Grant Nos. 81570880 and11675122), the National Key Research and Development Program of China (2016YFE0107000, 2016YFC0102500), 111 Project (D16011), Zhejiang Provincial Natural Science Foundation of China (Grant No. LY16H160047), and Public Service Program of Wenzhou Science and Technology Bureau (Y20160151). Disclosure: W.R. Kwapong, None; H. Ye, None; C. Peng, None; X. Zhuang, None; J. Wang, None; M. Shen, None; F. Lu, None
PY - 2018/8
Y1 - 2018/8
N2 - PURPOSE. To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson’s disease (PD) and find a correlation between the microvascular impairment and the neuronal damage. METHODS. This is a prospective, observational study including 49 eyes from 38 PD patients in their early stages and 34 eyes from 28 healthy controls with comparable age range. Macula microvasculature was evaluated with the spectral-domain optical coherence tomography (SD-OCT) angiography and intraretinal layer thickness evaluated with the SD-OCT. A custom algorithm was used for custom segmentation of retinal thickness and quantification of the superficial and deep microvascular density of the macula, respectively. RESULTS. PD patients showed reduced microvascular density in most of the areas of the whole retina. In the superficial retinal capillary plexus, statistical difference (P < 0.01) was seen in the total annular zone (TAZ), superior, temporal, inferior, and nasal zones. In PD patients, there was a strong correlation between the average ganglion cell layer and inner plexiform (GCIP) thickness and the TAZ of the superficial microvascular density (r = 0.062, P = 0.032). C ONCLUSION . We demonstrated that retinal microvascular density decreased in PD patients. The correlation between microvascular impairment in the superficial retinal capillary layer and GCIP thinning also revealed that the retinal microvascular abnormality may contribute to the neurodegeneration in PD patients. OCT-A with quantitative analysis offers a new path of study and will likely be useful in the future as an objective biomarker for detecting vessel impairment in early stages of PD.
AB - PURPOSE. To detect the retinal microvascular impairment using optical coherence tomography angiography (OCT-A) in patients with Parkinson’s disease (PD) and find a correlation between the microvascular impairment and the neuronal damage. METHODS. This is a prospective, observational study including 49 eyes from 38 PD patients in their early stages and 34 eyes from 28 healthy controls with comparable age range. Macula microvasculature was evaluated with the spectral-domain optical coherence tomography (SD-OCT) angiography and intraretinal layer thickness evaluated with the SD-OCT. A custom algorithm was used for custom segmentation of retinal thickness and quantification of the superficial and deep microvascular density of the macula, respectively. RESULTS. PD patients showed reduced microvascular density in most of the areas of the whole retina. In the superficial retinal capillary plexus, statistical difference (P < 0.01) was seen in the total annular zone (TAZ), superior, temporal, inferior, and nasal zones. In PD patients, there was a strong correlation between the average ganglion cell layer and inner plexiform (GCIP) thickness and the TAZ of the superficial microvascular density (r = 0.062, P = 0.032). C ONCLUSION . We demonstrated that retinal microvascular density decreased in PD patients. The correlation between microvascular impairment in the superficial retinal capillary layer and GCIP thinning also revealed that the retinal microvascular abnormality may contribute to the neurodegeneration in PD patients. OCT-A with quantitative analysis offers a new path of study and will likely be useful in the future as an objective biomarker for detecting vessel impairment in early stages of PD.
KW - Optical coherence tomographic angiography
KW - Parkinson’s disease
KW - Retinal microvasculature
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U2 - 10.1167/iovs.17-23230
DO - 10.1167/iovs.17-23230
M3 - Article
C2 - 30098201
AN - SCOPUS:85051565545
VL - 59
SP - 4115
EP - 4122
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 10
ER -