Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats

Kevin Park, Xueting Luo, Skyler J. Mooney, Benjamin J. Yungher, Stephane Belin, Chen Wang, Melissa M. Holmes, Zhigang He

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the adult mammalian central nervous system (CNS), axonal damage often triggers neuronal cell death and glial activation, with very limited spontaneous axon regeneration. In this study, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maximum life span exceeding 30 years, and found that injury responses in this species are quite distinct from those in other mammalian species. In contrast to what is seen in other mammals, the majority of injured retinal ganglion cells (RGCs) survive with relatively high spontaneous axon regeneration. Furthermore, injured RGCs display activated signal transducer and activator of transcription-3 (STAT3), whereas astrocytes in the optic nerve robustly occupy and fill the lesion area days after injury. These neuron-intrinsic and -extrinsic injury responses are reminiscent of those in "cold-blooded" animals, such as fish and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mechanisms of neuronal injury responses and axon regeneration in mammals. J. Comp. Neurol., 2016.

Original languageEnglish (US)
JournalJournal of Comparative Neurology
DOIs
StateAccepted/In press - 2016

Fingerprint

Mole Rats
Optic Nerve Injuries
Retinal Ganglion Cells
Axons
Regeneration
Cell Survival
Wounds and Injuries
Mammals
STAT3 Transcription Factor
Amphibians
Optic Nerve
Neuroglia
Astrocytes
Rodentia
Fishes
Cell Death
Central Nervous System
Neurons

Keywords

  • Axon growth. RRID:IMSR_JAX:000664
  • Axon injury
  • Axon regeneration
  • Naked mole-rat
  • Retinal ganglion cell
  • RRID:AB_10063408
  • RRID:AB_10694681
  • RRID:AB_143165
  • RRID:AB_143165
  • RRID:AB_2532994
  • RRID:AB_2534074
  • RRID:AB_2535855
  • RRID:AB_561305

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats. / Park, Kevin; Luo, Xueting; Mooney, Skyler J.; Yungher, Benjamin J.; Belin, Stephane; Wang, Chen; Holmes, Melissa M.; He, Zhigang.

In: Journal of Comparative Neurology, 2016.

Research output: Contribution to journalArticle

Park, Kevin ; Luo, Xueting ; Mooney, Skyler J. ; Yungher, Benjamin J. ; Belin, Stephane ; Wang, Chen ; Holmes, Melissa M. ; He, Zhigang. / Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats. In: Journal of Comparative Neurology. 2016.
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