Abstract
The clinical management of glaucoma and optic neuropathies has traditionally focused on stages of the diseases at which there are congruent losses of visual function and optic nerve tissue. Increasing clinical and experimental evidence suggests that the electrical activity of retinal ganglion cells, as measured by pattern electroretinogram (PERG), may be altered long before measurable changes in the thickness of the retinal nerve fiber layer. In addition, PERG alterations in early glaucoma may be either reversed by lowering the intraocular pressure or induced with head-down body posture. Here we apply the well-known concept of neural plasticity to model the reversible/inducible changes of retinal ganglion cell electrical activity during a critical period of dysfunction preceding death. Identification and characterization of this stage of modifiable retinal ganglion cell function represents both a rationale and a target for treatment to change the natural history of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 354-358 |
| Number of pages | 5 |
| Journal | Journal of Neuro-Ophthalmology |
| Volume | 32 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 2012 |
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ASJC Scopus subject areas
- Clinical Neurology
- Ophthalmology
Cite this
Retinal ganglion cell functional plasticity and optic neuropathy : A comprehensive model. / Porciatti, Vittorio; Ventura, Lori M.
In: Journal of Neuro-Ophthalmology, Vol. 32, No. 4, 01.12.2012, p. 354-358.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Retinal ganglion cell functional plasticity and optic neuropathy
T2 - A comprehensive model
AU - Porciatti, Vittorio
AU - Ventura, Lori M.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - The clinical management of glaucoma and optic neuropathies has traditionally focused on stages of the diseases at which there are congruent losses of visual function and optic nerve tissue. Increasing clinical and experimental evidence suggests that the electrical activity of retinal ganglion cells, as measured by pattern electroretinogram (PERG), may be altered long before measurable changes in the thickness of the retinal nerve fiber layer. In addition, PERG alterations in early glaucoma may be either reversed by lowering the intraocular pressure or induced with head-down body posture. Here we apply the well-known concept of neural plasticity to model the reversible/inducible changes of retinal ganglion cell electrical activity during a critical period of dysfunction preceding death. Identification and characterization of this stage of modifiable retinal ganglion cell function represents both a rationale and a target for treatment to change the natural history of the disease.
AB - The clinical management of glaucoma and optic neuropathies has traditionally focused on stages of the diseases at which there are congruent losses of visual function and optic nerve tissue. Increasing clinical and experimental evidence suggests that the electrical activity of retinal ganglion cells, as measured by pattern electroretinogram (PERG), may be altered long before measurable changes in the thickness of the retinal nerve fiber layer. In addition, PERG alterations in early glaucoma may be either reversed by lowering the intraocular pressure or induced with head-down body posture. Here we apply the well-known concept of neural plasticity to model the reversible/inducible changes of retinal ganglion cell electrical activity during a critical period of dysfunction preceding death. Identification and characterization of this stage of modifiable retinal ganglion cell function represents both a rationale and a target for treatment to change the natural history of the disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=84871239003&partnerID=8YFLogxK
U2 - 10.1097/WNO.0b013e3182745600
DO - 10.1097/WNO.0b013e3182745600
M3 - Article
C2 - 23196946
AN - SCOPUS:84871239003
VL - 32
SP - 354
EP - 358
JO - Journal of Neuro-Ophthalmology
JF - Journal of Neuro-Ophthalmology
SN - 1070-8022
IS - 4
ER -