Retinal detachment after subretinal stem cell transplantation

Ella H. Leung, Harry W. Flynn, Thomas A. Albini, Carlos A. Medina

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


A 60-year-old man with Stargardt's macular dystrophy and visual acuity of 20/400 in the right eye and 20/60 in the left eye underwent a subretinal injection of autologous bone marrow-derived stem cells in the right eye. The patient developed a retinal detachment in the right eye 2 months later that was initially treated with a scleral buckle, but the patient subsequently developed a recurrent retinal detachment with proliferative vitreoretinopathy. A pars plana vitrectomy, membrane peel, fluid-air exchange, endolaser, and silicone oil injection were then performed. The retina remained attached 5 months later, with improvement in visual acuity from hand motions to 20/300 post-vitrectomy. Retinal detachment may occur after subretinal injection of stem cells. Proliferative vitreoretinopathy may develop in these patients, but the visual acuity may return to baseline after retinal reattachment.

Original languageEnglish (US)
Pages (from-to)600-601
Number of pages2
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number6
StatePublished - Jun 2016

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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