Retinal deimination in aging and disease

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

Deimination is a posttranslational modification and refers to the conversion of protein bound arginine into citrulline. In the retina, deimination is predominantly catalyzed by Peptidylarginine deiminase type 2 (PAD2). PAD2 expression and deimination are found in many different retinal layers: choroid, retinal pigment epithelium (RPE), photoreceptors, inner plexiform layer, inner nuclear layer, and retinal ganglion cell (RGC) layer. Although decreased retinal deimination and PAD2 expression have been found during normal aging, elevated PAD2 expression and deimination have been observed in age-related neurodegenerative diseases. The role of deimination in normal physiology and in late-onset and progressive ocular or retinal degenerative diseases, such as glaucoma and experimental autoimmune encephalomyelitis remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)504-509
Number of pages6
JournalIUBMB life
Volume61
Issue number5
DOIs
StatePublished - Dec 1 2009

Keywords

  • Ageing
  • Arginine metabolism
  • Complex diseases
  • Enzymology
  • Neurodegenerative disorders
  • Protein function
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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