Retinal blood flow in glaucomatous eyes with single-hemifield damage

Mitra Sehi, Iman Goharian, Ranjith Konduru, Ou Tan, Sowmya Srinivas, Srinivas R. Sadda, Brian A. Francis, David Huang, David Greenfield

Research output: Contribution to journalArticle

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Abstract

Purpose To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere. Design Prospective, nonrandomized, case-control study. Participants Thirty eyes of 30 patients with glaucoma with visual field loss confined to a single hemifield and 27 eyes of 27 controls. Methods Normal and glaucomatous eyes underwent spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry. Doppler SD-OCT with a double-circle scanning pattern was used to measure RBF. The RBF was derived from the recorded Doppler frequency shift and the measured angle between the beam and the vessel. Total and hemispheric RBF, retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) values were calculated. The RS values were converted to 1/Lambert. Analysis of variance and regression analyses were performed. Main Outcome Measures Total and hemispheric RS, RBF, RNFL, and GCC values. Results The total RBF (34.6±12.2 μl/minute) and venous cross-sectional area (0.039±0.009 mm2) were reduced (P < 0.001) in those with glaucoma compared with controls (46.5±10.6 μl/minute; 0.052±0.012 mm2). Mean RBF was reduced in the abnormal hemisphere compared with the opposite hemisphere (15.3±5.4 vs. 19.3±8.4 μl/minute; P = 0.004). The RNFL and GCC were thinner in the corresponding abnormal hemisphere compared with the opposite hemisphere (87.0±20.2 vs. 103.7±20.6 μm, P = 0.002; 77.6±12.1 vs. 83.6±10.1 μm, P = 0.04). The RBF was correlated with RNFL (r = 0.41; P = 0.02) and GCC (r = 0.43; P = 0.02) but not the RS (r = 0.31; P = 0.09) in the abnormal hemisphere. The RBF (19.3±8.4 μl/minute), RNFL (103.7±20.6 μm), and GCC (83.6±10.1 μm) were reduced (P < 0.05) in the hemisphere with apparently normal visual field in glaucomatous eyes compared with the mean hemispheric values of the normal eyes (23.2±5.3 μl/minute, 124.8±9.6 μm, and 96.1±5.7 μm, respectively). Conclusions In glaucomatous eyes with single-hemifield damage, the RBF is significantly reduced in the hemisphere associated with the abnormal hemifield. Reduced RBF is associated with thinner RNFL and GCC in the corresponding abnormal hemisphere. Reduced RBF and RNFL and GCC loss also are observed in the perimetrically normal hemisphere of glaucomatous eyes.

Original languageEnglish
Pages (from-to)750-758
Number of pages9
JournalOphthalmology
Volume121
Issue number3
DOIs
StatePublished - Mar 1 2014

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Nerve Fibers
Ganglia
Optical Coherence Tomography
Visual Fields
Glaucoma
Analysis of Variance
Doppler Effect
Visual Field Tests
Case-Control Studies
Reference Values
Regression Analysis
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

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Sehi, M., Goharian, I., Konduru, R., Tan, O., Srinivas, S., Sadda, S. R., ... Greenfield, D. (2014). Retinal blood flow in glaucomatous eyes with single-hemifield damage. Ophthalmology, 121(3), 750-758. https://doi.org/10.1016/j.ophtha.2013.10.022

Retinal blood flow in glaucomatous eyes with single-hemifield damage. / Sehi, Mitra; Goharian, Iman; Konduru, Ranjith; Tan, Ou; Srinivas, Sowmya; Sadda, Srinivas R.; Francis, Brian A.; Huang, David; Greenfield, David.

In: Ophthalmology, Vol. 121, No. 3, 01.03.2014, p. 750-758.

Research output: Contribution to journalArticle

Sehi, M, Goharian, I, Konduru, R, Tan, O, Srinivas, S, Sadda, SR, Francis, BA, Huang, D & Greenfield, D 2014, 'Retinal blood flow in glaucomatous eyes with single-hemifield damage', Ophthalmology, vol. 121, no. 3, pp. 750-758. https://doi.org/10.1016/j.ophtha.2013.10.022
Sehi M, Goharian I, Konduru R, Tan O, Srinivas S, Sadda SR et al. Retinal blood flow in glaucomatous eyes with single-hemifield damage. Ophthalmology. 2014 Mar 1;121(3):750-758. https://doi.org/10.1016/j.ophtha.2013.10.022
Sehi, Mitra ; Goharian, Iman ; Konduru, Ranjith ; Tan, Ou ; Srinivas, Sowmya ; Sadda, Srinivas R. ; Francis, Brian A. ; Huang, David ; Greenfield, David. / Retinal blood flow in glaucomatous eyes with single-hemifield damage. In: Ophthalmology. 2014 ; Vol. 121, No. 3. pp. 750-758.
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abstract = "Purpose To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere. Design Prospective, nonrandomized, case-control study. Participants Thirty eyes of 30 patients with glaucoma with visual field loss confined to a single hemifield and 27 eyes of 27 controls. Methods Normal and glaucomatous eyes underwent spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry. Doppler SD-OCT with a double-circle scanning pattern was used to measure RBF. The RBF was derived from the recorded Doppler frequency shift and the measured angle between the beam and the vessel. Total and hemispheric RBF, retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) values were calculated. The RS values were converted to 1/Lambert. Analysis of variance and regression analyses were performed. Main Outcome Measures Total and hemispheric RS, RBF, RNFL, and GCC values. Results The total RBF (34.6±12.2 μl/minute) and venous cross-sectional area (0.039±0.009 mm2) were reduced (P < 0.001) in those with glaucoma compared with controls (46.5±10.6 μl/minute; 0.052±0.012 mm2). Mean RBF was reduced in the abnormal hemisphere compared with the opposite hemisphere (15.3±5.4 vs. 19.3±8.4 μl/minute; P = 0.004). The RNFL and GCC were thinner in the corresponding abnormal hemisphere compared with the opposite hemisphere (87.0±20.2 vs. 103.7±20.6 μm, P = 0.002; 77.6±12.1 vs. 83.6±10.1 μm, P = 0.04). The RBF was correlated with RNFL (r = 0.41; P = 0.02) and GCC (r = 0.43; P = 0.02) but not the RS (r = 0.31; P = 0.09) in the abnormal hemisphere. The RBF (19.3±8.4 μl/minute), RNFL (103.7±20.6 μm), and GCC (83.6±10.1 μm) were reduced (P < 0.05) in the hemisphere with apparently normal visual field in glaucomatous eyes compared with the mean hemispheric values of the normal eyes (23.2±5.3 μl/minute, 124.8±9.6 μm, and 96.1±5.7 μm, respectively). Conclusions In glaucomatous eyes with single-hemifield damage, the RBF is significantly reduced in the hemisphere associated with the abnormal hemifield. Reduced RBF is associated with thinner RNFL and GCC in the corresponding abnormal hemisphere. Reduced RBF and RNFL and GCC loss also are observed in the perimetrically normal hemisphere of glaucomatous eyes.",
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T1 - Retinal blood flow in glaucomatous eyes with single-hemifield damage

AU - Sehi, Mitra

AU - Goharian, Iman

AU - Konduru, Ranjith

AU - Tan, Ou

AU - Srinivas, Sowmya

AU - Sadda, Srinivas R.

AU - Francis, Brian A.

AU - Huang, David

AU - Greenfield, David

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Purpose To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere. Design Prospective, nonrandomized, case-control study. Participants Thirty eyes of 30 patients with glaucoma with visual field loss confined to a single hemifield and 27 eyes of 27 controls. Methods Normal and glaucomatous eyes underwent spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry. Doppler SD-OCT with a double-circle scanning pattern was used to measure RBF. The RBF was derived from the recorded Doppler frequency shift and the measured angle between the beam and the vessel. Total and hemispheric RBF, retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) values were calculated. The RS values were converted to 1/Lambert. Analysis of variance and regression analyses were performed. Main Outcome Measures Total and hemispheric RS, RBF, RNFL, and GCC values. Results The total RBF (34.6±12.2 μl/minute) and venous cross-sectional area (0.039±0.009 mm2) were reduced (P < 0.001) in those with glaucoma compared with controls (46.5±10.6 μl/minute; 0.052±0.012 mm2). Mean RBF was reduced in the abnormal hemisphere compared with the opposite hemisphere (15.3±5.4 vs. 19.3±8.4 μl/minute; P = 0.004). The RNFL and GCC were thinner in the corresponding abnormal hemisphere compared with the opposite hemisphere (87.0±20.2 vs. 103.7±20.6 μm, P = 0.002; 77.6±12.1 vs. 83.6±10.1 μm, P = 0.04). The RBF was correlated with RNFL (r = 0.41; P = 0.02) and GCC (r = 0.43; P = 0.02) but not the RS (r = 0.31; P = 0.09) in the abnormal hemisphere. The RBF (19.3±8.4 μl/minute), RNFL (103.7±20.6 μm), and GCC (83.6±10.1 μm) were reduced (P < 0.05) in the hemisphere with apparently normal visual field in glaucomatous eyes compared with the mean hemispheric values of the normal eyes (23.2±5.3 μl/minute, 124.8±9.6 μm, and 96.1±5.7 μm, respectively). Conclusions In glaucomatous eyes with single-hemifield damage, the RBF is significantly reduced in the hemisphere associated with the abnormal hemifield. Reduced RBF is associated with thinner RNFL and GCC in the corresponding abnormal hemisphere. Reduced RBF and RNFL and GCC loss also are observed in the perimetrically normal hemisphere of glaucomatous eyes.

AB - Purpose To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in the retinal hemisphere corresponding with the abnormal visual hemifield and that there are significant associations among reduced retinal sensitivity (RS) in the abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere. Design Prospective, nonrandomized, case-control study. Participants Thirty eyes of 30 patients with glaucoma with visual field loss confined to a single hemifield and 27 eyes of 27 controls. Methods Normal and glaucomatous eyes underwent spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry. Doppler SD-OCT with a double-circle scanning pattern was used to measure RBF. The RBF was derived from the recorded Doppler frequency shift and the measured angle between the beam and the vessel. Total and hemispheric RBF, retinal nerve fiber layer (RNFL), and ganglion cell complex (GCC) values were calculated. The RS values were converted to 1/Lambert. Analysis of variance and regression analyses were performed. Main Outcome Measures Total and hemispheric RS, RBF, RNFL, and GCC values. Results The total RBF (34.6±12.2 μl/minute) and venous cross-sectional area (0.039±0.009 mm2) were reduced (P < 0.001) in those with glaucoma compared with controls (46.5±10.6 μl/minute; 0.052±0.012 mm2). Mean RBF was reduced in the abnormal hemisphere compared with the opposite hemisphere (15.3±5.4 vs. 19.3±8.4 μl/minute; P = 0.004). The RNFL and GCC were thinner in the corresponding abnormal hemisphere compared with the opposite hemisphere (87.0±20.2 vs. 103.7±20.6 μm, P = 0.002; 77.6±12.1 vs. 83.6±10.1 μm, P = 0.04). The RBF was correlated with RNFL (r = 0.41; P = 0.02) and GCC (r = 0.43; P = 0.02) but not the RS (r = 0.31; P = 0.09) in the abnormal hemisphere. The RBF (19.3±8.4 μl/minute), RNFL (103.7±20.6 μm), and GCC (83.6±10.1 μm) were reduced (P < 0.05) in the hemisphere with apparently normal visual field in glaucomatous eyes compared with the mean hemispheric values of the normal eyes (23.2±5.3 μl/minute, 124.8±9.6 μm, and 96.1±5.7 μm, respectively). Conclusions In glaucomatous eyes with single-hemifield damage, the RBF is significantly reduced in the hemisphere associated with the abnormal hemifield. Reduced RBF is associated with thinner RNFL and GCC in the corresponding abnormal hemisphere. Reduced RBF and RNFL and GCC loss also are observed in the perimetrically normal hemisphere of glaucomatous eyes.

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