Retinal atrophy in eyes with resolved papilledema detected by optical coherence tomography

Brian Goldhagen, M. Tariq Bhatti, Pratul P. Srinivasan, Stephanie J. Chiu, Sina Farsiu, Mays A. El-Dairi

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. Methods: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuroophthalmology clinic between November 2010 and October 2011 were reviewed. Excluded were eyes with papilledema with Frisén grade >2, other optic neuropathies or retinopathies, and those that did not have SD-OCT imaging. The remaining 43 patients were split into 2 groups: non-atrophic papilledema and atrophic papilledema. Automated SD-OCT segmentation was performed on patients with non-atrophic papilledema and age-matched controls for each of the 9 regions of the Early Treatment Diabetic Retinopathy Study map. Bonferroni correction was used for multiple comparisons. All SD-OCT scans were reviewed for retinal structural abnormalities. Results: Total macular thickness was significantly thinner within the fovea and inner macular ring in non-atrophic papilledema vs control eyes (266 vs 276 μm, P = 0.04; 333 vs 344 μm P <0.01, n = 26 non-atrophic papilledema, 30 controls). SD-OCT demonstrated thinning within the fovea, inner macular ring, and outer macular ring of the outer plexiform layer plus nuclear layer in nonatrophic papilledema vs control (124 vs 131 μm, P <0.01; 112 vs 118 μm, P = 0.03; 95 vs 100 μm, P = 0.03). Retinal structural changes were seen in 21/33 eyes with atrophic papilledema vs none of the eyes with non-atrophic papilledema or controls. Conclusions: SD-OCT shows qualitative and quantitative changes in the macula of eyes with resolved papilledema.

Original languageEnglish (US)
Pages (from-to)122-123
Number of pages2
JournalJournal of Neuro-Ophthalmology
Volume35
Issue number2
DOIs
StatePublished - Jun 30 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology
  • Medicine(all)

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