Reticuloendothelial system (RES) hyperfunction and erythropoietin (Ep) production in the regenerating liver

B. A. Naughton, David Birnbach, P. Liu, G. A. Kolks, M. Z. Tung, J. A. Piliero, S. J. Piliero, A. S. Gordon

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Abstract

Hepatic cells in rats were evaluated after subtotal hepatectomy using scintillation scanning with technetium sulfur colloid (TSC), autoradiography, and microstereology techniques. The ability of the liver to accumulate TSC increased during the course of the regeneration as did the labeling of Kupffer and parenchymal cells with tritiated thymidine ( 3H-tdR). Kupffer to parenchymal cell number ratios and Kupffer cell relative areas were also elevated, attaining peak values at 72 hours post-hepatectomy. This period corresponds to the time of peak erythropoietin (Ep) production in rats with regenerating livers after nephrectomy and exposure to hypoxia. These findings suggest that the Kupffer cell may function as a cellular site of Ep formation.

Original languageEnglish
Pages (from-to)227-242
Number of pages16
JournalJournal of Surgical Oncology
Volume12
Issue number3
DOIs
StatePublished - Dec 1 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Naughton, B. A., Birnbach, D., Liu, P., Kolks, G. A., Tung, M. Z., Piliero, J. A., Piliero, S. J., & Gordon, A. S. (1979). Reticuloendothelial system (RES) hyperfunction and erythropoietin (Ep) production in the regenerating liver. Journal of Surgical Oncology, 12(3), 227-242. https://doi.org/10.1002/jso.2930120307