Abstract
For several decades, there has been increasing interest in the possible use of resveratrol as a preventative agent in cardiovascular disease. Resveratrol exerts numerous effects on adipocyte, hepatocyte, and endothelial cell development and function. Many investigations have demonstrated the ability of resveratrol to regulate the adipocyte lifecycle, lipid synthesis, and improve hepatic lipid metabolism. Resveratrol has numerous vascular protective effects on endothelial tissue, including its antiplatelet activity. Resveratrol also reduces intracellular oxidative stress. Animal models of obesity and cardiovascular diseases have yielded important contributions to our understanding of the effects of resveratrol on the vasculature and the risk for pathology. In limited human studies, resveratrol reduces the release of proinflammatory cytokines and improves systemic glucose and insulin regulation and decreases cellular oxidative stress. Therefore, resveratrol has significant potential as both a prophylactic and treatment agent. However additional studies are required to more completely characterize its impacts on human physiology and its benefits in the setting of disease.
| Original language | English |
|---|---|
| Pages (from-to) | 9-16 |
| Number of pages | 8 |
| Journal | Current Cardiovascular Risk Reports |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 21 2013 |
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Keywords
- Adipocytes
- Cardiovascular disease
- Inflammation
- Lipids
- Oxidative stress
- Resveratrol
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
Resveratrol : Effects on Lipids and Cardiovascular Risk. / Cherniack, Evan Paul; Troen, Bruce R.
In: Current Cardiovascular Risk Reports, Vol. 7, No. 1, 21.01.2013, p. 9-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Resveratrol
T2 - Effects on Lipids and Cardiovascular Risk
AU - Cherniack, Evan Paul
AU - Troen, Bruce R.
PY - 2013/1/21
Y1 - 2013/1/21
N2 - For several decades, there has been increasing interest in the possible use of resveratrol as a preventative agent in cardiovascular disease. Resveratrol exerts numerous effects on adipocyte, hepatocyte, and endothelial cell development and function. Many investigations have demonstrated the ability of resveratrol to regulate the adipocyte lifecycle, lipid synthesis, and improve hepatic lipid metabolism. Resveratrol has numerous vascular protective effects on endothelial tissue, including its antiplatelet activity. Resveratrol also reduces intracellular oxidative stress. Animal models of obesity and cardiovascular diseases have yielded important contributions to our understanding of the effects of resveratrol on the vasculature and the risk for pathology. In limited human studies, resveratrol reduces the release of proinflammatory cytokines and improves systemic glucose and insulin regulation and decreases cellular oxidative stress. Therefore, resveratrol has significant potential as both a prophylactic and treatment agent. However additional studies are required to more completely characterize its impacts on human physiology and its benefits in the setting of disease.
AB - For several decades, there has been increasing interest in the possible use of resveratrol as a preventative agent in cardiovascular disease. Resveratrol exerts numerous effects on adipocyte, hepatocyte, and endothelial cell development and function. Many investigations have demonstrated the ability of resveratrol to regulate the adipocyte lifecycle, lipid synthesis, and improve hepatic lipid metabolism. Resveratrol has numerous vascular protective effects on endothelial tissue, including its antiplatelet activity. Resveratrol also reduces intracellular oxidative stress. Animal models of obesity and cardiovascular diseases have yielded important contributions to our understanding of the effects of resveratrol on the vasculature and the risk for pathology. In limited human studies, resveratrol reduces the release of proinflammatory cytokines and improves systemic glucose and insulin regulation and decreases cellular oxidative stress. Therefore, resveratrol has significant potential as both a prophylactic and treatment agent. However additional studies are required to more completely characterize its impacts on human physiology and its benefits in the setting of disease.
KW - Adipocytes
KW - Cardiovascular disease
KW - Inflammation
KW - Lipids
KW - Oxidative stress
KW - Resveratrol
UR - http://www.scopus.com/inward/record.url?scp=84872283843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872283843&partnerID=8YFLogxK
U2 - 10.1007/s12170-012-0289-2
DO - 10.1007/s12170-012-0289-2
M3 - Article
AN - SCOPUS:84872283843
VL - 7
SP - 9
EP - 16
JO - Current Cardiovascular Risk Reports
JF - Current Cardiovascular Risk Reports
SN - 1932-9520
IS - 1
ER -