Results of lower extremity amputations in patients with end-stage renal disease

Christos D. Dossa, Alexander D. Shepard, Aaron M. Amos, Warren L. Kupin, Daniel J. Reddy, Joseph P. Elliott, Judith M. Wilczewski, Calvin B. Ernst

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Purpose: The purpose of this study was to determine the impact of end-stage renal disease (ESRD) on the outcome of patients undergoing lower extremity (LE) amputation. Methods: Hospital charts and vascular surgery registry data were reviewed for all patients who underwent LE amputation over a consecutive 56-month period. The results of 84 patients with ESRD (137 amputations) were compared with 375 patients (442 amputations) without ESRD. Results: Hospital mortality rate was significantly greater in patients with ESRD than patients without ESRD, 24% versus 7% (p = 0.001). Patients with ESRD undergoing minor amputations had mortality rates three times greater than patients without ESRD undergoing major LE amputations. In patients with ESRD requiring bilateral or unilateral above-knee amputation hospital mortality rates were 43% and 38%, respectively. In addition, patients with ESRD were seven times more likely to undergo bilateral amputation than patients without ESRD over a mean follow-up period of 17 months. No kidney transplant patients died after amputation. Conclusion: ESRD has a profound negative impact on morbidity, mortality, and survival rates after LE amputation. Attempts at prevention of amputation with aggressive foot care and patient education in this high-risk group should be the focus of therapy.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalJournal of vascular surgery
Issue number1
StatePublished - Jul 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine


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