Results of large penetrating keratoplasty in microbial keratitis

Stephen M. Cristol, Eduardo C Alfonso, James H. Guildford, Thomas J. Roussel, William W Culbertson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Extensive corneal disease secondary to microbial keratitis can result in frank or impending corneal perforation requiring a large penetrating keratoplasty. In an 8-year period, 26 penetrating keratoplasties with recipient beds of ≤9.5 mm were performed on 22 eyes: 11 for bacterial keratitis, 10 for fungal keratitis, and one for a mixed bacterial and fungal keratitis. The graft failed in 18 of 19 eyes (94.7%), with a median time to failure of 12.9 weeks in bacterial keratitis and 4.0 weeks in fungal keratitis. After large keratoplasty, 17 of 20 eyes (85.0%) maintained the structural integrity of the globe. The remainder became phthisical or required enucleation. With preservation of the structural integrity of the globe, a subsequent smaller optical penetrating keratoplasty is an option in some of these eyes.

Original languageEnglish
Pages (from-to)571-576
Number of pages6
JournalCornea
Volume15
Issue number6
StatePublished - Nov 1 1996

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Penetrating Keratoplasty
Keratitis
Corneal Perforation
Corneal Diseases
Corneal Transplantation
Transplants

Keywords

  • Bacterial infections
  • Corneal transplantation
  • Corneal ulcer
  • Graft rejection
  • Keratitis
  • Mycoses
  • Penetrating keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Cristol, S. M., Alfonso, E. C., Guildford, J. H., Roussel, T. J., & Culbertson, W. W. (1996). Results of large penetrating keratoplasty in microbial keratitis. Cornea, 15(6), 571-576.

Results of large penetrating keratoplasty in microbial keratitis. / Cristol, Stephen M.; Alfonso, Eduardo C; Guildford, James H.; Roussel, Thomas J.; Culbertson, William W.

In: Cornea, Vol. 15, No. 6, 01.11.1996, p. 571-576.

Research output: Contribution to journalArticle

Cristol, SM, Alfonso, EC, Guildford, JH, Roussel, TJ & Culbertson, WW 1996, 'Results of large penetrating keratoplasty in microbial keratitis', Cornea, vol. 15, no. 6, pp. 571-576.
Cristol SM, Alfonso EC, Guildford JH, Roussel TJ, Culbertson WW. Results of large penetrating keratoplasty in microbial keratitis. Cornea. 1996 Nov 1;15(6):571-576.
Cristol, Stephen M. ; Alfonso, Eduardo C ; Guildford, James H. ; Roussel, Thomas J. ; Culbertson, William W. / Results of large penetrating keratoplasty in microbial keratitis. In: Cornea. 1996 ; Vol. 15, No. 6. pp. 571-576.
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