Restorative effect of epinephrine on the electrophysiologic properties of depressed human atrial tissue

Henry Gelband, Michael R. Rosen, Robert J Myerburg, Harry L. Bush, Arthur L. Bassett, Brian F. Hoffman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The effects of epinephrine on the electrophysiologic properties of human right atrial tissue, obtained at cardiac surgery, were evaluated utilizing standard microelectrode techniques. In studies of electrophysiology, epinephrine had little effect on the resting membrane potential and transmembrane action potentials of normal atrial fibers. Epinephrine enhanced phase-4 depolarization and increased automaticity in normal fibers but hyperpolarized partially depolarized atrial fibers and decreased automaticity. The hyperpolarizing action of epinephrine resulted in a increase in action potential amplitude and dV/dt and enhanced conduction. Active force increased 40-230% in depressed tissues when exposed to epinephrine. Epinephrine-induced hyperpolarization of depressed atrial fibers may have a beneficial effect on atrial arrhythmias and depressed contractility encountered clinically.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalJournal of Electrocardiology
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

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Epinephrine
Membrane Potentials
Action Potentials
Ownership
Electrophysiology
Microelectrodes
Thoracic Surgery
Cardiac Arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Restorative effect of epinephrine on the electrophysiologic properties of depressed human atrial tissue. / Gelband, Henry; Rosen, Michael R.; Myerburg, Robert J; Bush, Harry L.; Bassett, Arthur L.; Hoffman, Brian F.

In: Journal of Electrocardiology, Vol. 10, No. 4, 01.01.1977, p. 313-320.

Research output: Contribution to journalArticle

Gelband, Henry ; Rosen, Michael R. ; Myerburg, Robert J ; Bush, Harry L. ; Bassett, Arthur L. ; Hoffman, Brian F. / Restorative effect of epinephrine on the electrophysiologic properties of depressed human atrial tissue. In: Journal of Electrocardiology. 1977 ; Vol. 10, No. 4. pp. 313-320.
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