Restoration of retinal ganglion cell function in early glaucoma after intraocular pressure reduction: A pilot study

Lori M. Ventura, Vittorio Porciatti

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

To investigate the changes of pattern electroretinogram (PERG) after intraocular pressure lowering in glaucoma patients and normal controls. Interventional retrospective cross-sectional study. Twenty-five patients (49 eyes) with ocular hypertension or glaucoma undergoing topical treatment to lower IOP served as a study group; 22 patients (44 eyes) with ocular hypertension or glaucoma observed without treatment served as a control group for treated glaucoma patients; 9 normal subjects (18 eyes) receiving a 250-mg acetazolamide tablet served as a second study group; and 17 normal subjects (34 eyes) from a previous study served as a second control group for treated normal subjects. Pattern electroretinograms were recorded simultaneously from both eyes using skin electrodes and automated analysis. Visual field (VF) analyses were performed with white-on-white standard automated perimetry (SAP). Intraocular pressure was measured with Goldmann applanation tonometry; central corneal thickness was measured with pachymetry. Pattern electroretinogram amplitude (microvolts), phase (π rads), and test-retest variability (test 2-to-test 1 ratio, in decibels), SAP mean deviation (decibels), and IOP (millimeters of mercury). In 56% of right eyes and 21% of left eyes of the treated glaucoma subgroup, the PERG amplitude and/or phase improved beyond the 95% confidence intervals of the test-retest variability of the untreated glaucoma control group. Pattern electroretinogram improvement with IOP lowering occurred in both high- and low-tension glaucoma eyes. Eyes with severely impaired VFs showed little improvement in PERG; however, eyes of normal subjects treated with acetazolamide did not show significant PERG changes relative to the test-retest variability of normal controls. Retinal ganglion cell function can be at least partially restored after IOP reduction in glaucomatous eyes with early VF impairment.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalOphthalmology
Volume112
Issue number1
DOIs
StatePublished - Jan 1 2005

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Retinal Ganglion Cells
Intraocular Pressure
Glaucoma
Ocular Hypertension
Visual Field Tests
Acetazolamide
Visual Fields
Control Groups
Low Tension Glaucoma
Vision Disorders
Manometry
Mercury
Tablets
Electrodes
Cross-Sectional Studies
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

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Restoration of retinal ganglion cell function in early glaucoma after intraocular pressure reduction : A pilot study. / Ventura, Lori M.; Porciatti, Vittorio.

In: Ophthalmology, Vol. 112, No. 1, 01.01.2005, p. 20-27.

Research output: Contribution to journalArticle

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