Restoration of hypoglycemia awareness after islet transplantation

Cristiane B. Leitão, Thipaporn Tharavanij, Pablo Cure, Antonello Pileggi, David A. Baidal, Camillo Ricordi, Rodolfo Alejandro

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


OBJECTIVE - To determine the impact of islet transplantation (ITx) on hypoglycemia awareness in patients with unstable type 1 diabetes and its relation to islet function. RESEARCH DESIGN AND METHODS - A total of 31 ITx recipients were studied. Hypoglycemia unawareness was assessed using the Clarke hypoglycemic score (0 = no hypoglycemia; ≥4 = hypoglycemia unawareness). Subjects were grouped based on graft function: off-insulin (n = 8), graft dysfunction (on-insulin and stimulated C-peptide ≥0.3 ng/ml, n = 13), and graft failure (stimulated C-peptide <0.3 ng/ml, n = 10, evaluated 11.5 ± 14.5 months after graft failure). RESULTS - The hypoglycemia score improved after ITx when compared with baseline values (before vs. after: 5.29 ± 1.51 vs. 1.35 ± 1.92, P < 0.001). This result was sustained even after patient stratification based on islet function (pre vs. post off-insulin: 5.63 ± 2.00 vs. no hypoglycemia reported; graft dysfunction: 5.31 ± 1.49 vs. 1.15 ± 1.63, P < 0.001; and graft failure: 5.00 ± 1.16 vs. 2.70 ± 2.26, P = 0.014). CONCLUSIONS - The improved metabolic control achieved with ITx can restore hypo- glycemia awareness in patients with type 1 diabetes, persisting even after islet graft failure.

Original languageEnglish (US)
Pages (from-to)2113-2115
Number of pages3
JournalDiabetes care
Issue number11
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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