Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity

A. Pertzelan, R. Keret, B. Bauman, Z. Josefsberg, Z. Ben-Zeev, B. Szoke, A. M. Comaru-Schally, Andrew V Schally, Z. Laron

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The response of plasma hGH to an iv bolus injection of GRH1-44 (1 μg/kg) was studied in 14 obese juveniles with a mean overweight of 4.7 ± 0.05 standard deviation score (SDS). Two patterns of response were observed: in all 7 adolescents with 'simple' obesity not related to any particular disorder (group A) the response was good (a mean of 11.8 ± 2.4 ng/ml) whereas in 6 of the 7 juveniles suffering from syndromes associated with obesity (group B) the response was poor (a mean of 3.2 ± 1.4 ng/ml). This divergence in response could not be related to a difference in the degree of overweight. These results indicate that in group B with syndromes associated with obesity there may also be a pituitary impairment in addition to the hypothalamic defect.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalActa Endocrinologica
Volume111
Issue number2
StatePublished - May 21 1986
Externally publishedYes

Fingerprint

Obesity
Injections

ASJC Scopus subject areas

  • Endocrinology

Cite this

Pertzelan, A., Keret, R., Bauman, B., Josefsberg, Z., Ben-Zeev, Z., Szoke, B., ... Laron, Z. (1986). Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity. Acta Endocrinologica, 111(2), 151-153.

Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity. / Pertzelan, A.; Keret, R.; Bauman, B.; Josefsberg, Z.; Ben-Zeev, Z.; Szoke, B.; Comaru-Schally, A. M.; Schally, Andrew V; Laron, Z.

In: Acta Endocrinologica, Vol. 111, No. 2, 21.05.1986, p. 151-153.

Research output: Contribution to journalArticle

Pertzelan, A, Keret, R, Bauman, B, Josefsberg, Z, Ben-Zeev, Z, Szoke, B, Comaru-Schally, AM, Schally, AV & Laron, Z 1986, 'Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity', Acta Endocrinologica, vol. 111, no. 2, pp. 151-153.
Pertzelan A, Keret R, Bauman B, Josefsberg Z, Ben-Zeev Z, Szoke B et al. Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity. Acta Endocrinologica. 1986 May 21;111(2):151-153.
Pertzelan, A. ; Keret, R. ; Bauman, B. ; Josefsberg, Z. ; Ben-Zeev, Z. ; Szoke, B. ; Comaru-Schally, A. M. ; Schally, Andrew V ; Laron, Z. / Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity. In: Acta Endocrinologica. 1986 ; Vol. 111, No. 2. pp. 151-153.
@article{b9cd4cad4c7947ee96c556ec1d7c003d,
title = "Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity",
abstract = "The response of plasma hGH to an iv bolus injection of GRH1-44 (1 μg/kg) was studied in 14 obese juveniles with a mean overweight of 4.7 ± 0.05 standard deviation score (SDS). Two patterns of response were observed: in all 7 adolescents with 'simple' obesity not related to any particular disorder (group A) the response was good (a mean of 11.8 ± 2.4 ng/ml) whereas in 6 of the 7 juveniles suffering from syndromes associated with obesity (group B) the response was poor (a mean of 3.2 ± 1.4 ng/ml). This divergence in response could not be related to a difference in the degree of overweight. These results indicate that in group B with syndromes associated with obesity there may also be a pituitary impairment in addition to the hypothalamic defect.",
author = "A. Pertzelan and R. Keret and B. Bauman and Z. Josefsberg and Z. Ben-Zeev and B. Szoke and Comaru-Schally, {A. M.} and Schally, {Andrew V} and Z. Laron",
year = "1986",
month = "5",
day = "21",
language = "English",
volume = "111",
pages = "151--153",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "2",

}

TY - JOUR

T1 - Responsiveness of pituitary hGH to GRH1-44 in juveniles with obesity

AU - Pertzelan, A.

AU - Keret, R.

AU - Bauman, B.

AU - Josefsberg, Z.

AU - Ben-Zeev, Z.

AU - Szoke, B.

AU - Comaru-Schally, A. M.

AU - Schally, Andrew V

AU - Laron, Z.

PY - 1986/5/21

Y1 - 1986/5/21

N2 - The response of plasma hGH to an iv bolus injection of GRH1-44 (1 μg/kg) was studied in 14 obese juveniles with a mean overweight of 4.7 ± 0.05 standard deviation score (SDS). Two patterns of response were observed: in all 7 adolescents with 'simple' obesity not related to any particular disorder (group A) the response was good (a mean of 11.8 ± 2.4 ng/ml) whereas in 6 of the 7 juveniles suffering from syndromes associated with obesity (group B) the response was poor (a mean of 3.2 ± 1.4 ng/ml). This divergence in response could not be related to a difference in the degree of overweight. These results indicate that in group B with syndromes associated with obesity there may also be a pituitary impairment in addition to the hypothalamic defect.

AB - The response of plasma hGH to an iv bolus injection of GRH1-44 (1 μg/kg) was studied in 14 obese juveniles with a mean overweight of 4.7 ± 0.05 standard deviation score (SDS). Two patterns of response were observed: in all 7 adolescents with 'simple' obesity not related to any particular disorder (group A) the response was good (a mean of 11.8 ± 2.4 ng/ml) whereas in 6 of the 7 juveniles suffering from syndromes associated with obesity (group B) the response was poor (a mean of 3.2 ± 1.4 ng/ml). This divergence in response could not be related to a difference in the degree of overweight. These results indicate that in group B with syndromes associated with obesity there may also be a pituitary impairment in addition to the hypothalamic defect.

UR - http://www.scopus.com/inward/record.url?scp=0022572187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022572187&partnerID=8YFLogxK

M3 - Article

C2 - 3082093

AN - SCOPUS:0022572187

VL - 111

SP - 151

EP - 153

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 2

ER -