TY - JOUR
T1 - Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men
AU - Gonzalez-Barcena, David
AU - Kastin, Abba J.
AU - Schalch, Don S.
AU - Torres-Zamora, Manuel
AU - Perez-Pasten, Enrique
AU - Kato, Alicia
AU - Schally, Andrew V.
PY - 1973/1
Y1 - 1973/1
N2 - Thyrotropin-releasing hormone (TRH) was administered iv to 8 patients with renal failure, 8 normal men, and 5 children. Injection of 1600 μg TRH as a bolus to healthy adults or a smaller dose to children resulted in a normal pattern of TSH release. The prolonged release of TSH which occurred after stat injection of 400 μg TRH to the patients with greatly diminished renal function was similar to that found after a 4-hr infusion of 1600 μg in normal men. In the men receiving the iv infusion, TSH levels began to diminish after 2 hr, despite the continued infusion of TRH for an additional 2 hr. An unexpected increase of hGH was also found in 7 of 8 patients with renal failure after injection of TRH.
AB - Thyrotropin-releasing hormone (TRH) was administered iv to 8 patients with renal failure, 8 normal men, and 5 children. Injection of 1600 μg TRH as a bolus to healthy adults or a smaller dose to children resulted in a normal pattern of TSH release. The prolonged release of TSH which occurred after stat injection of 400 μg TRH to the patients with greatly diminished renal function was similar to that found after a 4-hr infusion of 1600 μg in normal men. In the men receiving the iv infusion, TSH levels began to diminish after 2 hr, despite the continued infusion of TRH for an additional 2 hr. An unexpected increase of hGH was also found in 7 of 8 patients with renal failure after injection of TRH.
UR - http://www.scopus.com/inward/record.url?scp=0015542358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015542358&partnerID=8YFLogxK
U2 - 10.1210/jcem-36-1-117
DO - 10.1210/jcem-36-1-117
M3 - Article
C2 - 4117985
AN - SCOPUS:0015542358
VL - 36
SP - 117
EP - 120
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 1
ER -
