Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men

David Gonzalez-Barcena; Abba J. Kastin; Don S. Schalch; Manuel Torres-Zamora; Enrique Perez-Pasten; Alicia Kato; Andrew V. Schally

doi:10.1210/jcem-36-1-117

Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men

David Gonzalez-Barcena, Abba J. Kastin, Don S. Schalch, Manuel Torres-Zamora, Enrique Perez-Pasten, Alicia Kato, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Thyrotropin-releasing hormone (TRH) was administered iv to 8 patients with renal failure, 8 normal men, and 5 children. Injection of 1600 μg TRH as a bolus to healthy adults or a smaller dose to children resulted in a normal pattern of TSH release. The prolonged release of TSH which occurred after stat injection of 400 μg TRH to the patients with greatly diminished renal function was similar to that found after a 4-hr infusion of 1600 μg in normal men. In the men receiving the iv infusion, TSH levels began to diminish after 2 hr, despite the continued infusion of TRH for an additional 2 hr. An unexpected increase of hGH was also found in 7 of 8 patients with renal failure after injection of TRH.

Original language	English (US)
Pages (from-to)	117-120
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	36
Issue number	1
DOIs	https://doi.org/10.1210/jcem-36-1-117
State	Published - Jan 1973
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

UN SDGs

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Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men. / Gonzalez-Barcena, David; Kastin, Abba J.; Schalch, Don S.; Torres-Zamora, Manuel; Perez-Pasten, Enrique; Kato, Alicia; Schally, Andrew V.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 36, No. 1, 01.1973, p. 117-120.

Research output: Contribution to journal › Article › peer-review

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abstract = "Thyrotropin-releasing hormone (TRH) was administered iv to 8 patients with renal failure, 8 normal men, and 5 children. Injection of 1600 μg TRH as a bolus to healthy adults or a smaller dose to children resulted in a normal pattern of TSH release. The prolonged release of TSH which occurred after stat injection of 400 μg TRH to the patients with greatly diminished renal function was similar to that found after a 4-hr infusion of 1600 μg in normal men. In the men receiving the iv infusion, TSH levels began to diminish after 2 hr, despite the continued infusion of TRH for an additional 2 hr. An unexpected increase of hGH was also found in 7 of 8 patients with renal failure after injection of TRH.",

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AU - Gonzalez-Barcena, David

AU - Kastin, Abba J.

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AU - Perez-Pasten, Enrique

AU - Kato, Alicia

AU - Schally, Andrew V.

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Responses to thyrotropin-releasing hormone in patients with renal failure and after infusion in normal men

Abstract

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