Responses of adipose tissue lipoprotein lipase to weight loss affect lipid levels and weight regain in women

Barbara J. Nicklas, Ellen M. Rogus, Dora Berman-Weinberg, Karen E. Dennis, Andrew P. Goldberg

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study determines whether changes in abdominal (ABD) and gluteal (GLT) adipose tissue lipoprotein lipase (LPL) activity in response to a 6-mo weight loss intervention, comprised of a hypocaloric diet and low-intensity walking, affect changes in body composition, fat distribution, lipid metabolism, and the magnitude of weight regain in 36 obese postmenopausal women. Average adipose tissue LPL activity did not change with an average 5.6-kg weight loss, but changes in LPL activity were inversely related to baseline LPL activity (ABD: r = -0.60, GLT: r = -0.48; P < 0.01). The loss of abdominal body fat and decreases in total and low-density lipoprotein cholesterol were greater in women whose adipose tissue LPL activity decreased with weight loss despite a similar loss of total body weight and fat mass. Moreover, weight regain after a 6-mo follow-up was less in women whose adipose tissue LPL activity decreased than in women whose LPL increased (ABD: 0.9 ± 0.5 vs. 2.8 ± 0.6 kg, P < 0.05; GLT: 0.2 ± 0.5 vs. 2.8 ± 0.5 kg, P < 0.01). These results suggest that a reduction in adipose tissue LPL activity with weight loss is associated with improvements in lipid metabolic risk factors with weight loss and with diminished weight regain in postmenopausal women.

Original languageEnglish
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume279
Issue number5 42-5
StatePublished - Dec 12 2000
Externally publishedYes

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Regain
Lipoprotein Lipase
Adipose Tissue
Weight Loss
Tissue
Lipids
Weights and Measures
Abdominal Fat
Fats
Body Fat Distribution
Nutrition
Body Composition
Lipid Metabolism
LDL Cholesterol
Walking
Body Weight
Diet
Chemical analysis

Keywords

  • Adipose tissue metabolism
  • Lipoprotein lipids
  • Obesity
  • Postmenopausal women
  • Weight gain

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry
  • Physiology (medical)

Cite this

Responses of adipose tissue lipoprotein lipase to weight loss affect lipid levels and weight regain in women. / Nicklas, Barbara J.; Rogus, Ellen M.; Berman-Weinberg, Dora; Dennis, Karen E.; Goldberg, Andrew P.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 279, No. 5 42-5, 12.12.2000.

Research output: Contribution to journalArticle

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