Response of luteinizing hormone and follicle stimulating hormone to different doses of D leucine 6 LH RH ethylamide in oligospermic patients

D. Turner, E. A. Turner, N. J. Aparicio, L. Schwarzstein, D. H. Coy, Andrew V Schally

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Abstract

The rise in luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels after intramuscular administration of D leucine 6 LH RH ethylamide was studied in seven patients with idiopathic normogonadotropic oligospermia. Four tests with 2.5, 5.0, 10.0, and 20.0 μg of the analog, respectively, were carried out at 8 A.M. on each subject. The interval between tests was 1 week. Serum levels of LH and FSH were determined by radioimmunoassay before (-15 and 0 minutes) and 2, 4, 6, 12 and 24 hours after each injection. No differences in the basal values for either hormone were observed. D leucine 6 LH RH ethylamide produced significant increases in LH and FSH levels for 6 to 12 hours after the injection. Peak values were obtained between 4 and 6 hours. A dose response relationship for both gonadotropins was observed. The highest average levels of LH and FSH were obtained after injection of 20.0 μg of the drug. A great individual variation in magnitude of response was observed which seemed to be related to the functional reserve of the pituitary. It is suggested that doses of 10.0 to 20.0 μg of D leucine 6 LH RH ethylamide/day could be used for chronic treatment in male infertility.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalFertility and Sterility
Volume27
Issue number5
StatePublished - Dec 1 1976
Externally publishedYes

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Follicle Stimulating Hormone
Luteinizing Hormone
Leucine
Injections
Oligospermia
Male Infertility
Gonadotropins
Radioimmunoassay
Hormones
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Response of luteinizing hormone and follicle stimulating hormone to different doses of D leucine 6 LH RH ethylamide in oligospermic patients. / Turner, D.; Turner, E. A.; Aparicio, N. J.; Schwarzstein, L.; Coy, D. H.; Schally, Andrew V.

In: Fertility and Sterility, Vol. 27, No. 5, 01.12.1976, p. 545-548.

Research output: Contribution to journalArticle

Turner, D. ; Turner, E. A. ; Aparicio, N. J. ; Schwarzstein, L. ; Coy, D. H. ; Schally, Andrew V. / Response of luteinizing hormone and follicle stimulating hormone to different doses of D leucine 6 LH RH ethylamide in oligospermic patients. In: Fertility and Sterility. 1976 ; Vol. 27, No. 5. pp. 545-548.
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