RESPONSE OF HUMAN-IMMUNODEFICIENCY-VIRUS-ASSOCIATED NEUROLOGICAL DISEASE TO 3'-AZIDO-3'-DEOXYTHYMIDINE

Robert Yarchoan, Pim Brouwers, A. Robert Spitzer, Jordan Grafman, Bijan Safai, Carlo F. Perno, Steven M. Larson, Gary Berg, Margaret A. Fischl, Alison Wichman, Rose V. Thomas, Arturo Brunetti, Peter J. Schmidt, Charles E. Myers, Samuel Broder

Research output: Contribution to journalArticlepeer-review

245 Scopus citations

Abstract

Four patients with human-immunodeficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalThe Lancet
Volume329
Issue number8525
DOIs
StatePublished - Jan 17 1987

ASJC Scopus subject areas

  • Medicine(all)

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