Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness

Rogene F. Henderson, Edward B. Barr, Walter B. Blackwell, Connie R. Clark, Carole A. Conn, Roma Kalra, Thomas H. March, Mohan L. Sopori, Yohannes Tesfaigzi, Margaret G. Ménache, Deborah C. Mash, Karol Dokladny, Wieslaw Kozak, Anna Kozak, Maceij Wachulec, Karin Rudolph, Matthew J. Kluger, Shashi P. Singh, Seddigheh Razani-Boroujerdi, Raymond J. Langley

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

Original languageEnglish (US)
Pages (from-to)294-297
Number of pages4
JournalToxicology and Industrial Health
Volume17
Issue number10
DOIs
StatePublished - Jun 2001

Keywords

  • Cholinergic receptors
  • Immne system
  • Nerve gas
  • Sarin

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Health, Toxicology and Mutagenesis

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    Henderson, R. F., Barr, E. B., Blackwell, W. B., Clark, C. R., Conn, C. A., Kalra, R., March, T. H., Sopori, M. L., Tesfaigzi, Y., Ménache, M. G., Mash, D. C., Dokladny, K., Kozak, W., Kozak, A., Wachulec, M., Rudolph, K., Kluger, M. J., Singh, S. P., Razani-Boroujerdi, S., & Langley, R. J. (2001). Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness. Toxicology and Industrial Health, 17(10), 294-297. https://doi.org/10.1191/0748233701th105oa