Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness

Rogene F. Henderson, Edward B. Barr, Walter B. Blackwell, Connie R. Clark, Carole A. Conn, Roma Kalra, Thomas H. March, Mohan L. Sopori, Yohannes Tesfaigzi, Margaret G. Ménache, Deborah C Mash, Karol Dokladny, Wieslaw Kozak, Anna Kozak, Maceij Wachulec, Karin Rudolph, Matthew J. Kluger, Shashi P. Singh, Seddigheh Razani-Boroujerdi, Raymond J. Langley

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalToxicology and Industrial Health
Volume17
Issue number5-10
StatePublished - Jun 1 2001

Fingerprint

Sarin
Gulf War
Inbred F344 Rats
Memory Disorders
Inhalation
Rats
Immune System
Immune system
Brain
Data storage equipment
Cognitive Dysfunction
Nerve Agents

Keywords

  • Cholinergic receptors
  • Immne system
  • Nerve gas
  • Sarin

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Henderson, R. F., Barr, E. B., Blackwell, W. B., Clark, C. R., Conn, C. A., Kalra, R., ... Langley, R. J. (2001). Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness. Toxicology and Industrial Health, 17(5-10), 294-297.

Response of F344 rats to inhalation of subclinical levels of sarin : Exploring potential causes of Gulf War illness. / Henderson, Rogene F.; Barr, Edward B.; Blackwell, Walter B.; Clark, Connie R.; Conn, Carole A.; Kalra, Roma; March, Thomas H.; Sopori, Mohan L.; Tesfaigzi, Yohannes; Ménache, Margaret G.; Mash, Deborah C; Dokladny, Karol; Kozak, Wieslaw; Kozak, Anna; Wachulec, Maceij; Rudolph, Karin; Kluger, Matthew J.; Singh, Shashi P.; Razani-Boroujerdi, Seddigheh; Langley, Raymond J.

In: Toxicology and Industrial Health, Vol. 17, No. 5-10, 01.06.2001, p. 294-297.

Research output: Contribution to journalArticle

Henderson, RF, Barr, EB, Blackwell, WB, Clark, CR, Conn, CA, Kalra, R, March, TH, Sopori, ML, Tesfaigzi, Y, Ménache, MG, Mash, DC, Dokladny, K, Kozak, W, Kozak, A, Wachulec, M, Rudolph, K, Kluger, MJ, Singh, SP, Razani-Boroujerdi, S & Langley, RJ 2001, 'Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness', Toxicology and Industrial Health, vol. 17, no. 5-10, pp. 294-297.
Henderson RF, Barr EB, Blackwell WB, Clark CR, Conn CA, Kalra R et al. Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness. Toxicology and Industrial Health. 2001 Jun 1;17(5-10):294-297.
Henderson, Rogene F. ; Barr, Edward B. ; Blackwell, Walter B. ; Clark, Connie R. ; Conn, Carole A. ; Kalra, Roma ; March, Thomas H. ; Sopori, Mohan L. ; Tesfaigzi, Yohannes ; Ménache, Margaret G. ; Mash, Deborah C ; Dokladny, Karol ; Kozak, Wieslaw ; Kozak, Anna ; Wachulec, Maceij ; Rudolph, Karin ; Kluger, Matthew J. ; Singh, Shashi P. ; Razani-Boroujerdi, Seddigheh ; Langley, Raymond J. / Response of F344 rats to inhalation of subclinical levels of sarin : Exploring potential causes of Gulf War illness. In: Toxicology and Industrial Health. 2001 ; Vol. 17, No. 5-10. pp. 294-297.
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