Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness

Rogene F. Henderson; Edward B. Barr; Walter B. Blackwell; Connie R. Clark; Carole A. Conn; Roma Kalra; Thomas H. March; Mohan L. Sopori; Yohannes Tesfaigzi; Margaret G. Ménache; Deborah C. Mash; Karol Dokladny; Wieslaw Kozak; Anna Kozak; Maceij Wachulec; Karin Rudolph; Matthew J. Kluger; Shashi P. Singh; Seddigheh Razani-Boroujerdi; Raymond J. Langley

doi:10.1191/0748233701th105oa

Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness

Rogene F. Henderson, Edward B. Barr, Walter B. Blackwell, Connie R. Clark, Carole A. Conn, Roma Kalra, Thomas H. March, Mohan L. Sopori, Yohannes Tesfaigzi, Margaret G. Ménache, Deborah C. Mash, Karol Dokladny, Wieslaw Kozak, Anna Kozak, Maceij Wachulec, Karin Rudolph, Matthew J. Kluger, Shashi P. Singh, Seddigheh Razani-Boroujerdi, Raymond J. Langley

Neurology

Research output: Contribution to journal › Article

26 Scopus citations

Abstract

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

Original language	English (US)
Pages (from-to)	294-297
Number of pages	4
Journal	Toxicology and Industrial Health
Volume	17
Issue number	10
DOIs	https://doi.org/10.1191/0748233701th105oa
State	Published - Jun 2001

Keywords

Cholinergic receptors
Immne system
Nerve gas
Sarin

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Toxicology
Health, Toxicology and Mutagenesis

Access to Document

10.1191/0748233701th105oa

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Henderson, R. F., Barr, E. B., Blackwell, W. B., Clark, C. R., Conn, C. A., Kalra, R., March, T. H., Sopori, M. L., Tesfaigzi, Y., Ménache, M. G., Mash, D. C., Dokladny, K., Kozak, W., Kozak, A., Wachulec, M., Rudolph, K., Kluger, M. J., Singh, S. P., Razani-Boroujerdi, S., & Langley, R. J. (2001). Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness. Toxicology and Industrial Health, 17(10), 294-297. https://doi.org/10.1191/0748233701th105oa

Response of F344 rats to inhalation of subclinical levels of sarin : Exploring potential causes of Gulf War illness. / Henderson, Rogene F.; Barr, Edward B.; Blackwell, Walter B.; Clark, Connie R.; Conn, Carole A.; Kalra, Roma; March, Thomas H.; Sopori, Mohan L.; Tesfaigzi, Yohannes; Ménache, Margaret G.; Mash, Deborah C.; Dokladny, Karol; Kozak, Wieslaw; Kozak, Anna; Wachulec, Maceij; Rudolph, Karin; Kluger, Matthew J.; Singh, Shashi P.; Razani-Boroujerdi, Seddigheh; Langley, Raymond J.

In: Toxicology and Industrial Health, Vol. 17, No. 10, 06.2001, p. 294-297.

Research output: Contribution to journal › Article

Henderson, RF, Barr, EB, Blackwell, WB, Clark, CR, Conn, CA, Kalra, R, March, TH, Sopori, ML, Tesfaigzi, Y, Ménache, MG, Mash, DC, Dokladny, K, Kozak, W, Kozak, A, Wachulec, M, Rudolph, K, Kluger, MJ, Singh, SP, Razani-Boroujerdi, S & Langley, RJ 2001, 'Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness', Toxicology and Industrial Health, vol. 17, no. 10, pp. 294-297. https://doi.org/10.1191/0748233701th105oa

Henderson, Rogene F. ; Barr, Edward B. ; Blackwell, Walter B. ; Clark, Connie R. ; Conn, Carole A. ; Kalra, Roma ; March, Thomas H. ; Sopori, Mohan L. ; Tesfaigzi, Yohannes ; Ménache, Margaret G. ; Mash, Deborah C. ; Dokladny, Karol ; Kozak, Wieslaw ; Kozak, Anna ; Wachulec, Maceij ; Rudolph, Karin ; Kluger, Matthew J. ; Singh, Shashi P. ; Razani-Boroujerdi, Seddigheh ; Langley, Raymond J. / Response of F344 rats to inhalation of subclinical levels of sarin : Exploring potential causes of Gulf War illness. In: Toxicology and Industrial Health. 2001 ; Vol. 17, No. 10. pp. 294-297.

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