Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness

Rogene F. Henderson; Edward B. Barr; Walter B. Blackwell; Connie R. Clark; Carole A. Conn; Roma Kalra; Thomas H. March; Mohan L. Sopori; Yohannes Tesfaigzi; Margaret G. Ménache; Deborah C. Mash; Karol Dokladny; Wieslaw Kozak; Anna Kozak; Maceij Wachulec; Karin Rudolph; Matthew J. Kluger; Shashi P. Singh; Seddigheh Razani-Boroujerdi; Raymond J. Langley

doi:10.1191/0748233701th105oa

Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness

Rogene F. Henderson, Edward B. Barr, Walter B. Blackwell, Connie R. Clark, Carole A. Conn, Roma Kalra, Thomas H. March, Mohan L. Sopori, Yohannes Tesfaigzi, Margaret G. Ménache, Deborah C. Mash, Karol Dokladny, Wieslaw Kozak, Anna Kozak, Maceij Wachulec, Karin Rudolph, Matthew J. Kluger, Shashi P. Singh, Seddigheh Razani-Boroujerdi, Raymond J. Langley

Neurology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

Original language	English (US)
Pages (from-to)	294-297
Number of pages	4
Journal	Toxicology and Industrial Health
Volume	17
Issue number	10
DOIs	https://doi.org/10.1191/0748233701th105oa
State	Published - Jun 2001

Keywords

Cholinergic receptors
Immne system
Nerve gas
Sarin

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Toxicology
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1191/0748233701th105oa

Cite this

Henderson, R. F., Barr, E. B., Blackwell, W. B., Clark, C. R., Conn, C. A., Kalra, R., March, T. H., Sopori, M. L., Tesfaigzi, Y., Ménache, M. G., Mash, D. C., Dokladny, K., Kozak, W., Kozak, A., Wachulec, M., Rudolph, K., Kluger, M. J., Singh, S. P., Razani-Boroujerdi, S., & Langley, R. J. (2001). Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness. Toxicology and Industrial Health, 17(10), 294-297. https://doi.org/10.1191/0748233701th105oa

Response of F344 rats to inhalation of subclinical levels of sarin : Exploring potential causes of Gulf War illness. / Henderson, Rogene F.; Barr, Edward B.; Blackwell, Walter B.; Clark, Connie R.; Conn, Carole A.; Kalra, Roma; March, Thomas H.; Sopori, Mohan L.; Tesfaigzi, Yohannes; Ménache, Margaret G.; Mash, Deborah C.; Dokladny, Karol; Kozak, Wieslaw; Kozak, Anna; Wachulec, Maceij; Rudolph, Karin; Kluger, Matthew J.; Singh, Shashi P.; Razani-Boroujerdi, Seddigheh; Langley, Raymond J.

In: Toxicology and Industrial Health, Vol. 17, No. 10, 06.2001, p. 294-297.

Research output: Contribution to journal › Article › peer-review

Henderson, RF, Barr, EB, Blackwell, WB, Clark, CR, Conn, CA, Kalra, R, March, TH, Sopori, ML, Tesfaigzi, Y, Ménache, MG, Mash, DC, Dokladny, K, Kozak, W, Kozak, A, Wachulec, M, Rudolph, K, Kluger, MJ, Singh, SP, Razani-Boroujerdi, S & Langley, RJ 2001, 'Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness', Toxicology and Industrial Health, vol. 17, no. 10, pp. 294-297. https://doi.org/10.1191/0748233701th105oa

Henderson, Rogene F. ; Barr, Edward B. ; Blackwell, Walter B. ; Clark, Connie R. ; Conn, Carole A. ; Kalra, Roma ; March, Thomas H. ; Sopori, Mohan L. ; Tesfaigzi, Yohannes ; Ménache, Margaret G. ; Mash, Deborah C. ; Dokladny, Karol ; Kozak, Wieslaw ; Kozak, Anna ; Wachulec, Maceij ; Rudolph, Karin ; Kluger, Matthew J. ; Singh, Shashi P. ; Razani-Boroujerdi, Seddigheh ; Langley, Raymond J. / Response of F344 rats to inhalation of subclinical levels of sarin : Exploring potential causes of Gulf War illness. In: Toxicology and Industrial Health. 2001 ; Vol. 17, No. 10. pp. 294-297.

@article{785a78b2e3bf4160be13dc75e609a97b,

title = "Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness",

abstract = "Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.",

keywords = "Cholinergic receptors, Immne system, Nerve gas, Sarin",

author = "Henderson, {Rogene F.} and Barr, {Edward B.} and Blackwell, {Walter B.} and Clark, {Connie R.} and Conn, {Carole A.} and Roma Kalra and March, {Thomas H.} and Sopori, {Mohan L.} and Yohannes Tesfaigzi and M{\'e}nache, {Margaret G.} and Mash, {Deborah C.} and Karol Dokladny and Wieslaw Kozak and Anna Kozak and Maceij Wachulec and Karin Rudolph and Kluger, {Matthew J.} and Singh, {Shashi P.} and Seddigheh Razani-Boroujerdi and Langley, {Raymond J.}",

year = "2001",

month = jun,

doi = "10.1191/0748233701th105oa",

language = "English (US)",

volume = "17",

pages = "294--297",

journal = "Toxicology and Industrial Health",

issn = "0748-2337",

publisher = "SAGE Publications Ltd",

number = "10",

}

TY - JOUR

T1 - Response of F344 rats to inhalation of subclinical levels of sarin

T2 - Exploring potential causes of Gulf War illness

AU - Henderson, Rogene F.

AU - Barr, Edward B.

AU - Blackwell, Walter B.

AU - Clark, Connie R.

AU - Conn, Carole A.

AU - Kalra, Roma

AU - March, Thomas H.

AU - Sopori, Mohan L.

AU - Tesfaigzi, Yohannes

AU - Ménache, Margaret G.

AU - Mash, Deborah C.

AU - Dokladny, Karol

AU - Kozak, Wieslaw

AU - Kozak, Anna

AU - Wachulec, Maceij

AU - Rudolph, Karin

AU - Kluger, Matthew J.

AU - Singh, Shashi P.

AU - Razani-Boroujerdi, Seddigheh

AU - Langley, Raymond J.

PY - 2001/6

Y1 - 2001/6

N2 - Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

AB - Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.

KW - Cholinergic receptors

KW - Immne system

KW - Nerve gas

KW - Sarin

UR - http://www.scopus.com/inward/record.url?scp=0035384498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035384498&partnerID=8YFLogxK

U2 - 10.1191/0748233701th105oa

DO - 10.1191/0748233701th105oa

M3 - Article

C2 - 12539875

AN - SCOPUS:0035384498

VL - 17

SP - 294

EP - 297

JO - Toxicology and Industrial Health

JF - Toxicology and Industrial Health

SN - 0748-2337

IS - 10

ER -

Response of F344 rats to inhalation of subclinical levels of sarin: Exploring potential causes of Gulf War illness

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this