Response behavior of sodium-selective electrodes modified by surface attachment of the anticoagulant polysaccharides heparin and chondroitin sulfate

Ibrahim H.A. Badr, Jennifer Feiler, Leonidas G. Bachas

Research output: Contribution to journalArticle

9 Scopus citations


Two different polysaccharides with anticoagulant activities, heparin and chondroitin sulfate, were used to modify the surface of sodium-selective electrodes based on asymmetric cellulose triacetate (CTA) membranes. The membranes were formulated with sodium ionophore X, anionic additive, and o-nitrophenyl octyl ether. The response behavior of the surface-modified sodium electrodes was compared with that of control CTA, as well as poly(vinyl chloride) (PVC)-based sodium-selective electrodes. It was found that the selectivity coefficients obtained with the surface modified CTA membrane electrodes were slightly higher than those of the control, but in the case of heparin-modified electrodes they still met the requirements for analysis of sodium in physiological fluids within an error of <1%; the corresponding error for chondroitin sulfate-modified electrodes was also <1% except for the case of potassium ion in which the error was 1.3%. Likewise, it was found that other response characteristics, such as detection limit, linear range, slope of the response plot, selectivity pattern, and response time were comparable in both the control and the polysaccharide-modified electrodes. Therefore, the surface modification does not significantly alter the response behavior of the sensors.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
Issue number1
StatePublished - Jan 15 2005
Externally publishedYes



  • Biocompatibility
  • Cellulose triacetate
  • Chondroitin sulfate
  • Heparin
  • Ion-selective electrodes
  • Membrane electrodes

ASJC Scopus subject areas

  • Analytical Chemistry

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