Respiratory drive during carbachol challenge in allergic sheep

T. Strömberg, J. A. Adams, W. M. Abraham, M. A. Sackner

Research output: Contribution to journalArticle

Abstract

Diaphragmatic activity is the standard assessment of respiratory neural output but is difficult to measure and cannot be used for long-term clinical monitoring. The tidal breathing minute ventilation (V̄′) and mean inspiratory flow (VT/tI) reflect respiratory drive and can be monitored non-invasively using respiratory inductive plethysmography (RIP). Recent findings indicate that peak inspiratory acceleration (PIA) correlates to diaphragmatic activity during CO2 rebreathing in piglets. The aim of the present study was to assess whether tidal breathing peak inspiratory acceleration reflects respiratory drive during carbachol challenge. Aerosolized carbachol was administered to 15 allergic sheep until pulmonary resistance increased by at least 400%. After threshold dose, slight increases in V̄′ and VT/tI were seen (8 and 5%, respectively; P = NS), while PIA increased by 30% (P<0.05). The change in PIA was closely correlated to changes in V̄′ and VT/tI (r = 0.73, P<0.01 and r = 0.88, P<0.001, respectively). In conclusion, peak inspiratory acceleration reflected respiratory drive during bronchoprovocation. Further, this new measure of drive has the potential to accurately estimate drive in chronic obstructive lung disease where intrinsic positive end expiratory pressure prevents accurate selection of beginning inspiration necessary for computation of, e.g. VT/tI.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalClinical Physiology
Volume21
Issue number1
StatePublished - Mar 6 2001
Externally publishedYes

Fingerprint

Carbachol
Sheep
Respiration
Plethysmography
Positive-Pressure Respiration
Chronic Obstructive Pulmonary Disease
Ventilation
Lung

Keywords

  • Animals
  • Breathing pattern
  • Bronchial challenge
  • Monitoring
  • Respiratory inductive plethysmography

ASJC Scopus subject areas

  • Physiology

Cite this

Strömberg, T., Adams, J. A., Abraham, W. M., & Sackner, M. A. (2001). Respiratory drive during carbachol challenge in allergic sheep. Clinical Physiology, 21(1), 93-99.

Respiratory drive during carbachol challenge in allergic sheep. / Strömberg, T.; Adams, J. A.; Abraham, W. M.; Sackner, M. A.

In: Clinical Physiology, Vol. 21, No. 1, 06.03.2001, p. 93-99.

Research output: Contribution to journalArticle

Strömberg, T, Adams, JA, Abraham, WM & Sackner, MA 2001, 'Respiratory drive during carbachol challenge in allergic sheep', Clinical Physiology, vol. 21, no. 1, pp. 93-99.
Strömberg T, Adams JA, Abraham WM, Sackner MA. Respiratory drive during carbachol challenge in allergic sheep. Clinical Physiology. 2001 Mar 6;21(1):93-99.
Strömberg, T. ; Adams, J. A. ; Abraham, W. M. ; Sackner, M. A. / Respiratory drive during carbachol challenge in allergic sheep. In: Clinical Physiology. 2001 ; Vol. 21, No. 1. pp. 93-99.
@article{8c59e8f788714b0688c3cdeb929ef9c6,
title = "Respiratory drive during carbachol challenge in allergic sheep",
abstract = "Diaphragmatic activity is the standard assessment of respiratory neural output but is difficult to measure and cannot be used for long-term clinical monitoring. The tidal breathing minute ventilation (V̄′) and mean inspiratory flow (VT/tI) reflect respiratory drive and can be monitored non-invasively using respiratory inductive plethysmography (RIP). Recent findings indicate that peak inspiratory acceleration (PIA) correlates to diaphragmatic activity during CO2 rebreathing in piglets. The aim of the present study was to assess whether tidal breathing peak inspiratory acceleration reflects respiratory drive during carbachol challenge. Aerosolized carbachol was administered to 15 allergic sheep until pulmonary resistance increased by at least 400{\%}. After threshold dose, slight increases in V̄′ and VT/tI were seen (8 and 5{\%}, respectively; P = NS), while PIA increased by 30{\%} (P<0.05). The change in PIA was closely correlated to changes in V̄′ and VT/tI (r = 0.73, P<0.01 and r = 0.88, P<0.001, respectively). In conclusion, peak inspiratory acceleration reflected respiratory drive during bronchoprovocation. Further, this new measure of drive has the potential to accurately estimate drive in chronic obstructive lung disease where intrinsic positive end expiratory pressure prevents accurate selection of beginning inspiration necessary for computation of, e.g. VT/tI.",
keywords = "Animals, Breathing pattern, Bronchial challenge, Monitoring, Respiratory inductive plethysmography",
author = "T. Str{\"o}mberg and Adams, {J. A.} and Abraham, {W. M.} and Sackner, {M. A.}",
year = "2001",
month = "3",
day = "6",
language = "English",
volume = "21",
pages = "93--99",
journal = "Clinical Physiology and Functional Imaging",
issn = "1475-0961",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Respiratory drive during carbachol challenge in allergic sheep

AU - Strömberg, T.

AU - Adams, J. A.

AU - Abraham, W. M.

AU - Sackner, M. A.

PY - 2001/3/6

Y1 - 2001/3/6

N2 - Diaphragmatic activity is the standard assessment of respiratory neural output but is difficult to measure and cannot be used for long-term clinical monitoring. The tidal breathing minute ventilation (V̄′) and mean inspiratory flow (VT/tI) reflect respiratory drive and can be monitored non-invasively using respiratory inductive plethysmography (RIP). Recent findings indicate that peak inspiratory acceleration (PIA) correlates to diaphragmatic activity during CO2 rebreathing in piglets. The aim of the present study was to assess whether tidal breathing peak inspiratory acceleration reflects respiratory drive during carbachol challenge. Aerosolized carbachol was administered to 15 allergic sheep until pulmonary resistance increased by at least 400%. After threshold dose, slight increases in V̄′ and VT/tI were seen (8 and 5%, respectively; P = NS), while PIA increased by 30% (P<0.05). The change in PIA was closely correlated to changes in V̄′ and VT/tI (r = 0.73, P<0.01 and r = 0.88, P<0.001, respectively). In conclusion, peak inspiratory acceleration reflected respiratory drive during bronchoprovocation. Further, this new measure of drive has the potential to accurately estimate drive in chronic obstructive lung disease where intrinsic positive end expiratory pressure prevents accurate selection of beginning inspiration necessary for computation of, e.g. VT/tI.

AB - Diaphragmatic activity is the standard assessment of respiratory neural output but is difficult to measure and cannot be used for long-term clinical monitoring. The tidal breathing minute ventilation (V̄′) and mean inspiratory flow (VT/tI) reflect respiratory drive and can be monitored non-invasively using respiratory inductive plethysmography (RIP). Recent findings indicate that peak inspiratory acceleration (PIA) correlates to diaphragmatic activity during CO2 rebreathing in piglets. The aim of the present study was to assess whether tidal breathing peak inspiratory acceleration reflects respiratory drive during carbachol challenge. Aerosolized carbachol was administered to 15 allergic sheep until pulmonary resistance increased by at least 400%. After threshold dose, slight increases in V̄′ and VT/tI were seen (8 and 5%, respectively; P = NS), while PIA increased by 30% (P<0.05). The change in PIA was closely correlated to changes in V̄′ and VT/tI (r = 0.73, P<0.01 and r = 0.88, P<0.001, respectively). In conclusion, peak inspiratory acceleration reflected respiratory drive during bronchoprovocation. Further, this new measure of drive has the potential to accurately estimate drive in chronic obstructive lung disease where intrinsic positive end expiratory pressure prevents accurate selection of beginning inspiration necessary for computation of, e.g. VT/tI.

KW - Animals

KW - Breathing pattern

KW - Bronchial challenge

KW - Monitoring

KW - Respiratory inductive plethysmography

UR - http://www.scopus.com/inward/record.url?scp=21544480031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21544480031&partnerID=8YFLogxK

M3 - Article

C2 - 11168302

AN - SCOPUS:21544480031

VL - 21

SP - 93

EP - 99

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

SN - 1475-0961

IS - 1

ER -