Resolving the relationship between ApolipoproteinE and depression

Michael A. Slifer, Eden R Martin, John Gilbert, Jonathan L. Haines, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Several studies have reported an association between the ApolipoproteinE-ε4 (APOE4) allele and depression among elders. However others have failed to find an association. Since APOE4 is a well recognized risk factor for Alzheimer dementia, cognitive status may represent an important confounder between APOE4 and depression. In this investigation, we examined the relationship between the ApolipoproteinE-ε4 allele and depression among elders accounting for cognitive status. Using a case-control design (n = 1052), we investigated the association between ApolipoproteinE-ε4 and depression in Alzheimer disease patients (n = 528) and in cognitively intact controls (n = 524). We demonstrated an apparent association between the APOE4 allele and depression in the combined dataset (p = 0.001) when not controlling for cognitive status. However, once stratified by the presence of Alzheimer disease, there was no association in either the Alzheimer group (p = 0.290) or the cognitively intact controls (p = 0.494). In this dataset there is no association between the ApolipoproteinE-ε4 allele and depression among those with Alzheimer disease or among cognitively intact elders. However there is a significant association between female gender and depression in the cognitively intact (p = 0.003) but not among those with Alzheimer disease. Additionally, individuals with Alzheimer disease and depression had a significantly younger age of onset for their Alzheimer disease than those without depression (p = 0.017).

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalNeuroscience Letters
Volume455
Issue number2
DOIs
StatePublished - May 15 2009

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Depression
Alzheimer Disease
Alleles
Age of Onset

Keywords

  • Alzheimer disease
  • Apolipoprotein
  • Depression

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Resolving the relationship between ApolipoproteinE and depression. / Slifer, Michael A.; Martin, Eden R; Gilbert, John; Haines, Jonathan L.; Pericak-Vance, Margaret A.

In: Neuroscience Letters, Vol. 455, No. 2, 15.05.2009, p. 116-119.

Research output: Contribution to journalArticle

Slifer, Michael A. ; Martin, Eden R ; Gilbert, John ; Haines, Jonathan L. ; Pericak-Vance, Margaret A. / Resolving the relationship between ApolipoproteinE and depression. In: Neuroscience Letters. 2009 ; Vol. 455, No. 2. pp. 116-119.
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