Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: Two case reports

H. L. Ee, Gil Yosipovitch, R. Chan, B. H. Ong, Melvin Ee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Vulvitis circumscripta plasmacellularis (VCP) is a rare but well-described entity. It is notorious for its recalcitrant nature to various modalities of treatment. Intralesional interferon-α showed some promise, with complete resolution, but is coupled with the side-effect of myelosuppression. Topical imiquimod is a novel immune response modifier with the ability to induce the production of interferon-α. In this paper, we report two cases of VCP whose lesions were resistant to antibiotics, topical and oral corticosteroids, but resolved after a treatment trial with imiquimod.

Original languageEnglish (US)
Pages (from-to)638-641
Number of pages4
JournalBritish Journal of Dermatology
Volume149
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint

imiquimod
Vulvitis
Interferons
Adrenal Cortex Hormones
Anti-Bacterial Agents

Keywords

  • Imiquimod
  • Vulvitis circumscripta plasmacellularis
  • Zoon's vulvitis

ASJC Scopus subject areas

  • Dermatology

Cite this

Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod : Two case reports. / Ee, H. L.; Yosipovitch, Gil; Chan, R.; Ong, B. H.; Ee, Melvin.

In: British Journal of Dermatology, Vol. 149, No. 3, 01.09.2003, p. 638-641.

Research output: Contribution to journalArticle

@article{e8798baf1939489aaeb74923794a0cb1,
title = "Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod: Two case reports",
abstract = "Vulvitis circumscripta plasmacellularis (VCP) is a rare but well-described entity. It is notorious for its recalcitrant nature to various modalities of treatment. Intralesional interferon-α showed some promise, with complete resolution, but is coupled with the side-effect of myelosuppression. Topical imiquimod is a novel immune response modifier with the ability to induce the production of interferon-α. In this paper, we report two cases of VCP whose lesions were resistant to antibiotics, topical and oral corticosteroids, but resolved after a treatment trial with imiquimod.",
keywords = "Imiquimod, Vulvitis circumscripta plasmacellularis, Zoon's vulvitis",
author = "Ee, {H. L.} and Gil Yosipovitch and R. Chan and Ong, {B. H.} and Melvin Ee",
year = "2003",
month = "9",
day = "1",
doi = "10.1046/j.1365-2133.2003.05583.x",
language = "English (US)",
volume = "149",
pages = "638--641",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Resolution of vulvitis circumscripta plasmacellularis with topical imiquimod

T2 - Two case reports

AU - Ee, H. L.

AU - Yosipovitch, Gil

AU - Chan, R.

AU - Ong, B. H.

AU - Ee, Melvin

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Vulvitis circumscripta plasmacellularis (VCP) is a rare but well-described entity. It is notorious for its recalcitrant nature to various modalities of treatment. Intralesional interferon-α showed some promise, with complete resolution, but is coupled with the side-effect of myelosuppression. Topical imiquimod is a novel immune response modifier with the ability to induce the production of interferon-α. In this paper, we report two cases of VCP whose lesions were resistant to antibiotics, topical and oral corticosteroids, but resolved after a treatment trial with imiquimod.

AB - Vulvitis circumscripta plasmacellularis (VCP) is a rare but well-described entity. It is notorious for its recalcitrant nature to various modalities of treatment. Intralesional interferon-α showed some promise, with complete resolution, but is coupled with the side-effect of myelosuppression. Topical imiquimod is a novel immune response modifier with the ability to induce the production of interferon-α. In this paper, we report two cases of VCP whose lesions were resistant to antibiotics, topical and oral corticosteroids, but resolved after a treatment trial with imiquimod.

KW - Imiquimod

KW - Vulvitis circumscripta plasmacellularis

KW - Zoon's vulvitis

UR - http://www.scopus.com/inward/record.url?scp=0142120504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142120504&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2133.2003.05583.x

DO - 10.1046/j.1365-2133.2003.05583.x

M3 - Article

C2 - 14511002

AN - SCOPUS:0142120504

VL - 149

SP - 638

EP - 641

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 3

ER -