Resistance to thyroid hormone does not abrogate the transient thyrotoxicosis associated with gestation: Report of a case

João Anselmo, Teresa Kay, Kimberly Dennis, Russell Szmulewitz, Samuel Refetoff, Roy E. Weiss

Research output: Contribution to journalArticle

10 Scopus citations


We report the occurrence of transient thyrotoxicosis during pregnancy in a subject with resistance to thyroid hormone. Before pregnancy, the subject was euthyroid, with normal serum TSH and elevated levels of free T3 and free T4 caused by a mutation in the TRβ gene (R243Q). Beginning at the fourth week of gestation serum levels of free T3 and T4 increased in parallel with an increase in hCG. At 6-7 wk gestation she manifested hypermetabolic features, with mild nausea and vomiting. Peak levels of serum hCG and thyroid hormone concentrations were attained at 12 wk gestation, when serum TSH was fully suppressed. In the following weeks of gestation, thyroid hormone levels declined, with amelioration of the symptoms. A baby boy also affected with resistance to thyroid hormone harboring the same TRβ gene mutation was born by normal vaginal delivery.

Original languageEnglish (US)
Pages (from-to)4273-4275
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number9
StatePublished - Jan 1 2001


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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