TY - JOUR
T1 - Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure
T2 - a systematic review and meta-analysis
AU - Santos, Francisco V.
AU - Chiappa, Gaspar R.
AU - Ramalho, Sergio Henrique Rodolpho
AU - de Lima, Alexandra Correa Gervazoni Balbuena
AU - de Souza, Fausto Stauffer Junqueira
AU - Cahalin, Lawrence P
AU - Durigan, João Luiz Quagliotti
AU - de Castro, Isac
AU - Cipriano, Gerson
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Recent literature suggests that resistance training (RT) improves peak oxygen uptake (V ̇ O 2 peak), similarly to aerobic exercise (AE) in patients with heart failure (HF), but its effect on cardiac remodeling is controversial. Thus, we examined the effects of RT and AE on V ̇ O 2 peak and cardiac remodeling in patients with heart failure (HF) via a systematic review and meta-analysis. MEDLINE, EMBASE, Cochrane Library and CINAHL, AMEDEO and PEDro databases search were extracted study characteristics, exercise type, and ventricular outcomes. The main outcomes were V ̇ O 2 peak (ml kg−1 min−1), LVEF (%) and LVEDV (mL). Fifty-nine RCTs were included. RT produced a greater increase in V ̇ O 2 peak (3.57 ml kg−1 min−1, P < 0.00001, I2 = 0%) compared to AE (2.63 ml kg−1 min−1, P < 0.00001, I2 = 58%) while combined RT and AE produced a 2.48 ml kg−1 min−1 increase in V ̇ O 2; I2 = 69%) compared to control group. Comparison among the three forms of exercise revealed similar effects on V ̇ O 2 peak (P = 0.84 and 1.00, respectively; I2 = 0%). AE was associated with a greater gain in LVEF (3.15%; P < 0.00001, I2 = 17%) compared to RT alone or combined exercise which produced similar gains compared to control groups. Subgroup analysis revealed that AE reduced LVEDV (− 10.21 ml; P = 0.007, I2 = 0%), while RT and combined RT and AE had no effect on LVEDV compared with control participants. RT results in a greater gain in V ̇ O 2 peak, and induces no deleterious effects on cardiac function in HF patients.
AB - Recent literature suggests that resistance training (RT) improves peak oxygen uptake (V ̇ O 2 peak), similarly to aerobic exercise (AE) in patients with heart failure (HF), but its effect on cardiac remodeling is controversial. Thus, we examined the effects of RT and AE on V ̇ O 2 peak and cardiac remodeling in patients with heart failure (HF) via a systematic review and meta-analysis. MEDLINE, EMBASE, Cochrane Library and CINAHL, AMEDEO and PEDro databases search were extracted study characteristics, exercise type, and ventricular outcomes. The main outcomes were V ̇ O 2 peak (ml kg−1 min−1), LVEF (%) and LVEDV (mL). Fifty-nine RCTs were included. RT produced a greater increase in V ̇ O 2 peak (3.57 ml kg−1 min−1, P < 0.00001, I2 = 0%) compared to AE (2.63 ml kg−1 min−1, P < 0.00001, I2 = 58%) while combined RT and AE produced a 2.48 ml kg−1 min−1 increase in V ̇ O 2; I2 = 69%) compared to control group. Comparison among the three forms of exercise revealed similar effects on V ̇ O 2 peak (P = 0.84 and 1.00, respectively; I2 = 0%). AE was associated with a greater gain in LVEF (3.15%; P < 0.00001, I2 = 17%) compared to RT alone or combined exercise which produced similar gains compared to control groups. Subgroup analysis revealed that AE reduced LVEDV (− 10.21 ml; P = 0.007, I2 = 0%), while RT and combined RT and AE had no effect on LVEDV compared with control participants. RT results in a greater gain in V ̇ O 2 peak, and induces no deleterious effects on cardiac function in HF patients.
KW - Exercise capacity
KW - Heart failure
KW - Performance
KW - Ventricular remodeling
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U2 - 10.1007/s10741-017-9658-8
DO - 10.1007/s10741-017-9658-8
M3 - Review article
C2 - 29199385
AN - SCOPUS:85036505383
VL - 23
SP - 73
EP - 89
JO - Heart Failure Reviews
JF - Heart Failure Reviews
SN - 1382-4147
IS - 1
ER -