Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure

a systematic review and meta-analysis

Francisco V. Santos, Gaspar R. Chiappa, Sergio Henrique Rodolpho Ramalho, Alexandra Correa Gervazoni Balbuena de Lima, Fausto Stauffer Junqueira de Souza, Lawrence P Cahalin, João Luiz Quagliotti Durigan, Isac de Castro, Gerson Cipriano

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Recent literature suggests that resistance training (RT) improves peak oxygen uptake (V ̇ O 2 peak), similarly to aerobic exercise (AE) in patients with heart failure (HF), but its effect on cardiac remodeling is controversial. Thus, we examined the effects of RT and AE on V ̇ O 2 peak and cardiac remodeling in patients with heart failure (HF) via a systematic review and meta-analysis. MEDLINE, EMBASE, Cochrane Library and CINAHL, AMEDEO and PEDro databases search were extracted study characteristics, exercise type, and ventricular outcomes. The main outcomes were V ̇ O 2 peak (ml kg−1 min−1), LVEF (%) and LVEDV (mL). Fifty-nine RCTs were included. RT produced a greater increase in V ̇ O 2 peak (3.57 ml kg−1 min−1, P < 0.00001, I2 = 0%) compared to AE (2.63 ml kg−1 min−1, P < 0.00001, I2 = 58%) while combined RT and AE produced a 2.48 ml kg−1 min−1 increase in V ̇ O 2; I2 = 69%) compared to control group. Comparison among the three forms of exercise revealed similar effects on V ̇ O 2 peak (P = 0.84 and 1.00, respectively; I2 = 0%). AE was associated with a greater gain in LVEF (3.15%; P < 0.00001, I2 = 17%) compared to RT alone or combined exercise which produced similar gains compared to control groups. Subgroup analysis revealed that AE reduced LVEDV (− 10.21 ml; P = 0.007, I2 = 0%), while RT and combined RT and AE had no effect on LVEDV compared with control participants. RT results in a greater gain in V ̇ O 2 peak, and induces no deleterious effects on cardiac function in HF patients.

Original languageEnglish (US)
Pages (from-to)73-89
Number of pages17
JournalHeart Failure Reviews
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2018

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Systolic Heart Failure
Resistance Training
Meta-Analysis
Exercise
Oxygen
Heart Failure
Control Groups
MEDLINE
Libraries
Databases

Keywords

  • Exercise capacity
  • Heart failure
  • Performance
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure : a systematic review and meta-analysis. / Santos, Francisco V.; Chiappa, Gaspar R.; Ramalho, Sergio Henrique Rodolpho; de Lima, Alexandra Correa Gervazoni Balbuena; de Souza, Fausto Stauffer Junqueira; Cahalin, Lawrence P; Durigan, João Luiz Quagliotti; de Castro, Isac; Cipriano, Gerson.

In: Heart Failure Reviews, Vol. 23, No. 1, 01.01.2018, p. 73-89.

Research output: Contribution to journalReview article

Santos, Francisco V. ; Chiappa, Gaspar R. ; Ramalho, Sergio Henrique Rodolpho ; de Lima, Alexandra Correa Gervazoni Balbuena ; de Souza, Fausto Stauffer Junqueira ; Cahalin, Lawrence P ; Durigan, João Luiz Quagliotti ; de Castro, Isac ; Cipriano, Gerson. / Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure : a systematic review and meta-analysis. In: Heart Failure Reviews. 2018 ; Vol. 23, No. 1. pp. 73-89.
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AU - de Lima, Alexandra Correa Gervazoni Balbuena

AU - de Souza, Fausto Stauffer Junqueira

AU - Cahalin, Lawrence P

AU - Durigan, João Luiz Quagliotti

AU - de Castro, Isac

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