Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure: a systematic review and meta-analysis

Francisco V. Santos, Gaspar R. Chiappa, Sergio Henrique Rodolpho Ramalho, Alexandra Correa Gervazoni Balbuena de Lima, Fausto Stauffer Junqueira de Souza, Lawrence P Cahalin, João Luiz Quagliotti Durigan, Isac de Castro, Gerson Cipriano

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Recent literature suggests that resistance training (RT) improves peak oxygen uptake (V ̇ O 2 peak), similarly to aerobic exercise (AE) in patients with heart failure (HF), but its effect on cardiac remodeling is controversial. Thus, we examined the effects of RT and AE on V ̇ O 2 peak and cardiac remodeling in patients with heart failure (HF) via a systematic review and meta-analysis. MEDLINE, EMBASE, Cochrane Library and CINAHL, AMEDEO and PEDro databases search were extracted study characteristics, exercise type, and ventricular outcomes. The main outcomes were V ̇ O 2 peak (ml kg−1 min−1), LVEF (%) and LVEDV (mL). Fifty-nine RCTs were included. RT produced a greater increase in V ̇ O 2 peak (3.57 ml kg−1 min−1, P < 0.00001, I2 = 0%) compared to AE (2.63 ml kg−1 min−1, P < 0.00001, I2 = 58%) while combined RT and AE produced a 2.48 ml kg−1 min−1 increase in V ̇ O 2; I2 = 69%) compared to control group. Comparison among the three forms of exercise revealed similar effects on V ̇ O 2 peak (P = 0.84 and 1.00, respectively; I2 = 0%). AE was associated with a greater gain in LVEF (3.15%; P < 0.00001, I2 = 17%) compared to RT alone or combined exercise which produced similar gains compared to control groups. Subgroup analysis revealed that AE reduced LVEDV (− 10.21 ml; P = 0.007, I2 = 0%), while RT and combined RT and AE had no effect on LVEDV compared with control participants. RT results in a greater gain in V ̇ O 2 peak, and induces no deleterious effects on cardiac function in HF patients.

Original languageEnglish (US)
Pages (from-to)73-89
Number of pages17
JournalHeart Failure Reviews
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Exercise capacity
  • Heart failure
  • Performance
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Santos, F. V., Chiappa, G. R., Ramalho, S. H. R., de Lima, A. C. G. B., de Souza, F. S. J., Cahalin, L. P., Durigan, J. L. Q., de Castro, I., & Cipriano, G. (2018). Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure: a systematic review and meta-analysis. Heart Failure Reviews, 23(1), 73-89. https://doi.org/10.1007/s10741-017-9658-8