Abstract
Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 703-709 |
| Number of pages | 7 |
| Journal | NeuroReport |
| Volume | 19 |
| Issue number | 7 |
| DOIs | |
| State | Published - May 2008 |
| Externally published | Yes |
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Keywords
- Commissurotomy
- Diffusion tensor imaging
- Interhemispheric interaction
- Laterality
- Resting-state functional connectivity
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Residual functional connectivity in the split-brain revealed with resting-state functional MRI. / Uddin, Lucina Q; Mooshagian, Eric; Zaidel, Eran; Scheres, Anouk; Margulies, Daniel S.; Kelly, A. M C; Shehzad, Zarrar; Adelstein, Jonathan S.; Castellanos, F. Xavier; Biswal, Bharat B.; Milham, Michael P.
In: NeuroReport, Vol. 19, No. 7, 05.2008, p. 703-709.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Residual functional connectivity in the split-brain revealed with resting-state functional MRI
AU - Uddin, Lucina Q
AU - Mooshagian, Eric
AU - Zaidel, Eran
AU - Scheres, Anouk
AU - Margulies, Daniel S.
AU - Kelly, A. M C
AU - Shehzad, Zarrar
AU - Adelstein, Jonathan S.
AU - Castellanos, F. Xavier
AU - Biswal, Bharat B.
AU - Milham, Michael P.
PY - 2008/5
Y1 - 2008/5
N2 - Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
AB - Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
KW - Commissurotomy
KW - Diffusion tensor imaging
KW - Interhemispheric interaction
KW - Laterality
KW - Resting-state functional connectivity
UR - http://www.scopus.com/inward/record.url?scp=42349110235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42349110235&partnerID=8YFLogxK
U2 - 10.1097/WNR.0b013e3282fb8203
DO - 10.1097/WNR.0b013e3282fb8203
M3 - Article
C2 - 18418243
AN - SCOPUS:42349110235
VL - 19
SP - 703
EP - 709
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 7
ER -