Residual functional connectivity in the split-brain revealed with resting-state functional MRI

Lucina Q Uddin, Eric Mooshagian, Eran Zaidel, Anouk Scheres, Daniel S. Margulies, A. M C Kelly, Zarrar Shehzad, Jonathan S. Adelstein, F. Xavier Castellanos, Bharat B. Biswal, Michael P. Milham

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.

Original languageEnglish (US)
Pages (from-to)703-709
Number of pages7
JournalNeuroReport
Volume19
Issue number7
DOIs
StatePublished - May 2008
Externally publishedYes

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Split-Brain Procedure
Magnetic Resonance Imaging
Reference Values
Control Groups
Brain

Keywords

  • Commissurotomy
  • Diffusion tensor imaging
  • Interhemispheric interaction
  • Laterality
  • Resting-state functional connectivity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Uddin, L. Q., Mooshagian, E., Zaidel, E., Scheres, A., Margulies, D. S., Kelly, A. M. C., ... Milham, M. P. (2008). Residual functional connectivity in the split-brain revealed with resting-state functional MRI. NeuroReport, 19(7), 703-709. https://doi.org/10.1097/WNR.0b013e3282fb8203

Residual functional connectivity in the split-brain revealed with resting-state functional MRI. / Uddin, Lucina Q; Mooshagian, Eric; Zaidel, Eran; Scheres, Anouk; Margulies, Daniel S.; Kelly, A. M C; Shehzad, Zarrar; Adelstein, Jonathan S.; Castellanos, F. Xavier; Biswal, Bharat B.; Milham, Michael P.

In: NeuroReport, Vol. 19, No. 7, 05.2008, p. 703-709.

Research output: Contribution to journalArticle

Uddin, LQ, Mooshagian, E, Zaidel, E, Scheres, A, Margulies, DS, Kelly, AMC, Shehzad, Z, Adelstein, JS, Castellanos, FX, Biswal, BB & Milham, MP 2008, 'Residual functional connectivity in the split-brain revealed with resting-state functional MRI', NeuroReport, vol. 19, no. 7, pp. 703-709. https://doi.org/10.1097/WNR.0b013e3282fb8203
Uddin, Lucina Q ; Mooshagian, Eric ; Zaidel, Eran ; Scheres, Anouk ; Margulies, Daniel S. ; Kelly, A. M C ; Shehzad, Zarrar ; Adelstein, Jonathan S. ; Castellanos, F. Xavier ; Biswal, Bharat B. ; Milham, Michael P. / Residual functional connectivity in the split-brain revealed with resting-state functional MRI. In: NeuroReport. 2008 ; Vol. 19, No. 7. pp. 703-709.
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