Abstract
Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.
Original language | English (US) |
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Pages (from-to) | 703-709 |
Number of pages | 7 |
Journal | Neuroreport |
Volume | 19 |
Issue number | 7 |
DOIs | |
State | Published - May 2008 |
Keywords
- Commissurotomy
- Diffusion tensor imaging
- Interhemispheric interaction
- Laterality
- Resting-state functional connectivity
ASJC Scopus subject areas
- Neuroscience(all)