Residual functional connectivity in the split-brain revealed with resting-state functional MRI

Lucina Q. Uddin, Eric Mooshagian, Eran Zaidel, Anouk Scheres, Daniel S. Margulies, A. M.Clare Kelly, Zarrar Shehzad, Jonathan S. Adelstein, F. Xavier Castellanos, Bharat B. Biswal, Michael P. Milham

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Split-brain patients present a unique opportunity to address controversies regarding subcortical contributions to interhemispheric coordination. We characterized residual functional connectivity in a complete commissurotomy patient by examining patterns of low-frequency BOLD functional MRI signal. Using independent components analysis and region-of-interest-based functional connectivity analyses, we demonstrate bilateral resting state networks in a patient lacking all major cerebral commissures. Compared with a control group, the patient's interhemispheric correlation scores fell within the normal range for two out of three regions examined. Thus, we provide evidence for bilateral resting state networks in a patient with complete commissurotomy. Such continued interhemispheric interaction suggests that, at least in part, cortical networks in the brain can be coordinated by subcortical mechanisms.

Original languageEnglish (US)
Pages (from-to)703-709
Number of pages7
JournalNeuroreport
Volume19
Issue number7
DOIs
StatePublished - May 1 2008
Externally publishedYes

Keywords

  • Commissurotomy
  • Diffusion tensor imaging
  • Interhemispheric interaction
  • Laterality
  • Resting-state functional connectivity

ASJC Scopus subject areas

  • Neuroscience(all)

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    Uddin, L. Q., Mooshagian, E., Zaidel, E., Scheres, A., Margulies, D. S., Kelly, A. M. C., Shehzad, Z., Adelstein, J. S., Castellanos, F. X., Biswal, B. B., & Milham, M. P. (2008). Residual functional connectivity in the split-brain revealed with resting-state functional MRI. Neuroreport, 19(7), 703-709. https://doi.org/10.1097/WNR.0b013e3282fb8203