Residential segregation and overall survival of women with epithelial ovarian cancer

Ashly C. Westrick, Zinzi D. Bailey, Matthew Schlumbrecht, Way Way M. Hlaing, Erin E. Kobetz, Daniel J. Feaster, Raymond R. Balise

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: To the authors' knowledge, the etiology of survival disparities in patients with epithelial ovarian cancer (EOC) is not fully understood. Residential segregation, both economic and racial, remains a problem within the United States. The objective of the current study was to analyze the effect of residential segregation as measured by the Index of Concentration at the Extremes (ICE) on EOC survival in Florida by race and/or ethnicity. Methods: All malignant EOC cases were identified from 2001 through 2015 using the Florida Cancer Data System (FCDS). Census-defined places were used as proxies for neighborhoods. Using 5-year estimates from the American Community Survey, 5 ICE variables were computed: economic (high vs low), race and/or ethnicity (non-Hispanic white [NHW] vs non-Hispanic black [NHB] and NHW vs Hispanic), and racialized economic segregation (low-income NHB vs high-income NHW and low-income Hispanic vs high-income NHW). Random effects frailty models were conducted. Results: A total of 16,431 malignant EOC cases were diagnosed in Florida among women living in an assigned census-defined place within the time period. The authors found that economic and racialized economic residential segregations influenced EOC survival more than race and/or ethnic segregation alone in both NHB and Hispanic women. NHB women continued to have an increased hazard of death compared with NHW women after controlling for multiple covariates, whereas Hispanic women were found to have either a similar or decreased hazard of death compared with NHW women in multivariable Cox models. Conclusions: The results of the current study indicated that racial and economic residential segregation influences survival among patients with EOC. Research is needed to develop more robust segregation measures that capture the complexities of neighborhoods to fully understand the survival disparities in EOC.

Original languageEnglish (US)
Pages (from-to)3698-3707
Number of pages10
JournalCancer
Volume126
Issue number16
DOIs
StatePublished - Aug 15 2020

Keywords

  • Index of Concentration at the Extremes
  • ovarian cancer
  • residential segregation
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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