Research advances in the mutation of TET2 gene in myeloid maligancies

Rong Li, Mingjiang Xu, Feng-Chun Yang, Yuan Zhou

Research output: Contribution to journalReview article

Abstract

TET2 gene is a member of TET oncogene family. It has been reported as a tumor suppressor gene with important roles in myelopiesis. Recent studies have shown that TET2 protein takes part in demethylation by converting 5-methylcytosine (5-mc) into 5-hydroxymethylcytosine (5-hmc). Somatic TET2 inactivation leads to abnormal myelopiesis and myeloid malignancies. In this review, the structure and function of TET2 and the relationship between TET gene mutation and myeloid malignancies are summarized.

Original languageEnglish (US)
Pages (from-to)583-588
Number of pages6
JournalActa Academiae Medicinae Sinicae
Volume38
Issue number5
DOIs
StatePublished - Oct 30 2016
Externally publishedYes

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Keywords

  • Mutation
  • Myeloid malignancies
  • TET2

ASJC Scopus subject areas

  • Medicine(all)

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