Requirement of the nicotinic acetylcholine receptor β2 subunit for the anatomical and functional development of the visual system

Francesco Mattia Rossi, Tommaso Pizzorusso, Vittorio Porciatti, Lisa M. Marubio, Lamberto Maffei, Jean Pierre Changeux

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

In the mammalian visual system the formation of eye-specific layers at the thalamic level depends on retinal waves of spontaneous activity, which rely on nicotinic acetylcholine receptor activation. We found that in mutant mice lacking the β2 subunit of the neuronal nicotinic receptor, but not in mice lacking the α4 subunit, retinofugal projections do not segregate into eye-specific areas, both in the dorso-lateral geniculate nucleus and in the superior colliculus. Moreover, β2-/- mice show an expansion of the binocular subfield of the primary visual cortex and a decrease in visual acuity at the cortical level but not in the retina. We conclude that the β2 subunit of the nicotinic acetylcholine receptor is necessary for the anatomical and functional development of the visual system.

Original languageEnglish
Pages (from-to)6453-6458
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number11
DOIs
StatePublished - May 22 2001
Externally publishedYes

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Nicotinic Receptors
Geniculate Bodies
Superior Colliculi
Visual Cortex
Visual Acuity
Retina

ASJC Scopus subject areas

  • Genetics
  • General

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Requirement of the nicotinic acetylcholine receptor β2 subunit for the anatomical and functional development of the visual system. / Rossi, Francesco Mattia; Pizzorusso, Tommaso; Porciatti, Vittorio; Marubio, Lisa M.; Maffei, Lamberto; Changeux, Jean Pierre.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 11, 22.05.2001, p. 6453-6458.

Research output: Contribution to journalArticle

Rossi, Francesco Mattia ; Pizzorusso, Tommaso ; Porciatti, Vittorio ; Marubio, Lisa M. ; Maffei, Lamberto ; Changeux, Jean Pierre. / Requirement of the nicotinic acetylcholine receptor β2 subunit for the anatomical and functional development of the visual system. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 11. pp. 6453-6458.
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