Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes

Iman Goharian, Shawn M. Iverson, Rosa Catalina Ruiz, Krishna Kishor, David Greenfield, Mitra Sehi

Research output: Contribution to journalArticle

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Abstract

Aim: To measure the reproducibility of retinal oxygen saturation (SaO2) levels among treated glaucomatous eyes and normal controls in a prospective nonrandomised study. Methods: Patients with perimetric glaucoma (PG) and normal controls were included. Exclusion criteria for both groups included visual acuity <20/30, unreliable visual fields, thyroidopathies, hemoglobinopathies, cardiovascular and pulmonary diseases. Retinal oximetry was performed twice consecutively on one randomly selected eye of PG and normal controls using spectrophotometric retinal oximeter (SRO; Oxymap ehf., Iceland). Four main retinal vessel pairs were analysed separately. Coefficients of variability (CoV), coefficients of repeatability (CoR) and intraclass correlation coefficients (ICCs) in arteries (a.SaO2) and veins (v.SaO2) were calculated. Results: 23 PG (mean age 68.3±10.8 years) and 22 normal subjects (mean age 61.5±18.2 years; p=0.14) were included. The intraocular pressure and mean ocular perfusion pressure in glaucoma (14.4±4.2 mm Hg; 45.8 ±5.8 mm Hg) and controls (14.3±3.3 mm Hg; 45.8 ±6.1 mm Hg) were similar (p >0.05). In the PG group, the a.SaO2 had a CoV of 1.6%, a CoR of 4.7 and an ICC of 0.97; the v.SaO2 had a CoV of 5.9%, a CoR of 8.7 and an ICC of 0.96. In normals, the a.SaO2 had a CoV of 0.98%, a CoR of 3.3 and an ICC of 0.97; the v.SaO2 had a CoV of 4.8%, a CoR of 7.7 and an ICC of 0.93. Conclusions: Retinal oximetry measurements using SRO are highly reproducible in both treated glaucomatous and normal eyes.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalBritish Journal of Ophthalmology
Volume99
Issue number3
DOIs
StatePublished - Mar 1 2015

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Glaucoma
Oxygen
Oximetry
Visual Acuity
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes. / Goharian, Iman; Iverson, Shawn M.; Ruiz, Rosa Catalina; Kishor, Krishna; Greenfield, David; Sehi, Mitra.

In: British Journal of Ophthalmology, Vol. 99, No. 3, 01.03.2015, p. 318-322.

Research output: Contribution to journalArticle

Goharian, Iman ; Iverson, Shawn M. ; Ruiz, Rosa Catalina ; Kishor, Krishna ; Greenfield, David ; Sehi, Mitra. / Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes. In: British Journal of Ophthalmology. 2015 ; Vol. 99, No. 3. pp. 318-322.
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abstract = "Aim: To measure the reproducibility of retinal oxygen saturation (SaO2) levels among treated glaucomatous eyes and normal controls in a prospective nonrandomised study. Methods: Patients with perimetric glaucoma (PG) and normal controls were included. Exclusion criteria for both groups included visual acuity <20/30, unreliable visual fields, thyroidopathies, hemoglobinopathies, cardiovascular and pulmonary diseases. Retinal oximetry was performed twice consecutively on one randomly selected eye of PG and normal controls using spectrophotometric retinal oximeter (SRO; Oxymap ehf., Iceland). Four main retinal vessel pairs were analysed separately. Coefficients of variability (CoV), coefficients of repeatability (CoR) and intraclass correlation coefficients (ICCs) in arteries (a.SaO2) and veins (v.SaO2) were calculated. Results: 23 PG (mean age 68.3±10.8 years) and 22 normal subjects (mean age 61.5±18.2 years; p=0.14) were included. The intraocular pressure and mean ocular perfusion pressure in glaucoma (14.4±4.2 mm Hg; 45.8 ±5.8 mm Hg) and controls (14.3±3.3 mm Hg; 45.8 ±6.1 mm Hg) were similar (p >0.05). In the PG group, the a.SaO2 had a CoV of 1.6{\%}, a CoR of 4.7 and an ICC of 0.97; the v.SaO2 had a CoV of 5.9{\%}, a CoR of 8.7 and an ICC of 0.96. In normals, the a.SaO2 had a CoV of 0.98{\%}, a CoR of 3.3 and an ICC of 0.97; the v.SaO2 had a CoV of 4.8{\%}, a CoR of 7.7 and an ICC of 0.93. Conclusions: Retinal oximetry measurements using SRO are highly reproducible in both treated glaucomatous and normal eyes.",
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