Abstract
Aim: To measure the reproducibility of retinal oxygen saturation (SaO2) levels among treated glaucomatous eyes and normal controls in a prospective nonrandomised study. Methods: Patients with perimetric glaucoma (PG) and normal controls were included. Exclusion criteria for both groups included visual acuity <20/30, unreliable visual fields, thyroidopathies, hemoglobinopathies, cardiovascular and pulmonary diseases. Retinal oximetry was performed twice consecutively on one randomly selected eye of PG and normal controls using spectrophotometric retinal oximeter (SRO; Oxymap ehf., Iceland). Four main retinal vessel pairs were analysed separately. Coefficients of variability (CoV), coefficients of repeatability (CoR) and intraclass correlation coefficients (ICCs) in arteries (a.SaO2) and veins (v.SaO2) were calculated. Results: 23 PG (mean age 68.3±10.8 years) and 22 normal subjects (mean age 61.5±18.2 years; p=0.14) were included. The intraocular pressure and mean ocular perfusion pressure in glaucoma (14.4±4.2 mm Hg; 45.8 ±5.8 mm Hg) and controls (14.3±3.3 mm Hg; 45.8 ±6.1 mm Hg) were similar (p >0.05). In the PG group, the a.SaO2 had a CoV of 1.6%, a CoR of 4.7 and an ICC of 0.97; the v.SaO2 had a CoV of 5.9%, a CoR of 8.7 and an ICC of 0.96. In normals, the a.SaO2 had a CoV of 0.98%, a CoR of 3.3 and an ICC of 0.97; the v.SaO2 had a CoV of 4.8%, a CoR of 7.7 and an ICC of 0.93. Conclusions: Retinal oximetry measurements using SRO are highly reproducible in both treated glaucomatous and normal eyes.
| Original language | English |
|---|---|
| Pages (from-to) | 318-322 |
| Number of pages | 5 |
| Journal | British Journal of Ophthalmology |
| Volume | 99 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2015 |
Fingerprint
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes. / Goharian, Iman; Iverson, Shawn M.; Ruiz, Rosa Catalina; Kishor, Krishna; Greenfield, David; Sehi, Mitra.
In: British Journal of Ophthalmology, Vol. 99, No. 3, 01.03.2015, p. 318-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes
AU - Goharian, Iman
AU - Iverson, Shawn M.
AU - Ruiz, Rosa Catalina
AU - Kishor, Krishna
AU - Greenfield, David
AU - Sehi, Mitra
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Aim: To measure the reproducibility of retinal oxygen saturation (SaO2) levels among treated glaucomatous eyes and normal controls in a prospective nonrandomised study. Methods: Patients with perimetric glaucoma (PG) and normal controls were included. Exclusion criteria for both groups included visual acuity <20/30, unreliable visual fields, thyroidopathies, hemoglobinopathies, cardiovascular and pulmonary diseases. Retinal oximetry was performed twice consecutively on one randomly selected eye of PG and normal controls using spectrophotometric retinal oximeter (SRO; Oxymap ehf., Iceland). Four main retinal vessel pairs were analysed separately. Coefficients of variability (CoV), coefficients of repeatability (CoR) and intraclass correlation coefficients (ICCs) in arteries (a.SaO2) and veins (v.SaO2) were calculated. Results: 23 PG (mean age 68.3±10.8 years) and 22 normal subjects (mean age 61.5±18.2 years; p=0.14) were included. The intraocular pressure and mean ocular perfusion pressure in glaucoma (14.4±4.2 mm Hg; 45.8 ±5.8 mm Hg) and controls (14.3±3.3 mm Hg; 45.8 ±6.1 mm Hg) were similar (p >0.05). In the PG group, the a.SaO2 had a CoV of 1.6%, a CoR of 4.7 and an ICC of 0.97; the v.SaO2 had a CoV of 5.9%, a CoR of 8.7 and an ICC of 0.96. In normals, the a.SaO2 had a CoV of 0.98%, a CoR of 3.3 and an ICC of 0.97; the v.SaO2 had a CoV of 4.8%, a CoR of 7.7 and an ICC of 0.93. Conclusions: Retinal oximetry measurements using SRO are highly reproducible in both treated glaucomatous and normal eyes.
AB - Aim: To measure the reproducibility of retinal oxygen saturation (SaO2) levels among treated glaucomatous eyes and normal controls in a prospective nonrandomised study. Methods: Patients with perimetric glaucoma (PG) and normal controls were included. Exclusion criteria for both groups included visual acuity <20/30, unreliable visual fields, thyroidopathies, hemoglobinopathies, cardiovascular and pulmonary diseases. Retinal oximetry was performed twice consecutively on one randomly selected eye of PG and normal controls using spectrophotometric retinal oximeter (SRO; Oxymap ehf., Iceland). Four main retinal vessel pairs were analysed separately. Coefficients of variability (CoV), coefficients of repeatability (CoR) and intraclass correlation coefficients (ICCs) in arteries (a.SaO2) and veins (v.SaO2) were calculated. Results: 23 PG (mean age 68.3±10.8 years) and 22 normal subjects (mean age 61.5±18.2 years; p=0.14) were included. The intraocular pressure and mean ocular perfusion pressure in glaucoma (14.4±4.2 mm Hg; 45.8 ±5.8 mm Hg) and controls (14.3±3.3 mm Hg; 45.8 ±6.1 mm Hg) were similar (p >0.05). In the PG group, the a.SaO2 had a CoV of 1.6%, a CoR of 4.7 and an ICC of 0.97; the v.SaO2 had a CoV of 5.9%, a CoR of 8.7 and an ICC of 0.96. In normals, the a.SaO2 had a CoV of 0.98%, a CoR of 3.3 and an ICC of 0.97; the v.SaO2 had a CoV of 4.8%, a CoR of 7.7 and an ICC of 0.93. Conclusions: Retinal oximetry measurements using SRO are highly reproducible in both treated glaucomatous and normal eyes.
UR - http://www.scopus.com/inward/record.url?scp=84923253773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923253773&partnerID=8YFLogxK
U2 - 10.1136/bjophthalmol-2014-305718
DO - 10.1136/bjophthalmol-2014-305718
M3 - Article
C2 - 25253765
AN - SCOPUS:84923253773
VL - 99
SP - 318
EP - 322
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 3
ER -