Reproducibility and reliability of short-TE whole-brain MR spectroscopic imaging of human brain at 3T

Xiao Qi Ding, Andrew A. Maudsley, Mohammad Sabati, Sulaiman Sheriff, Paulo R. Dellani, Heinrich Lanfermann

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Purpose: A feasibility study of an echo-planar spectroscopic imaging (EPSI) using a short echo time (TE) that trades off sensitivity, compared with other short-TE methods, to achieve whole brain coverage using inversion recovery and spatial oversampling to control lipid bleeding. Methods: Twenty subjects were scanned to examine intersubject variance. One subject was scanned five times to examine intrasubject reproducibility. Data were analyzed to determine coefficients of variance (COV) and intraclass correlation coefficient (ICC) for N-acetylaspartate (NAA), total creatine (tCr), total choline (tCho), glutamine=glutamate (Glx), and myo-inositol (mI). Regional metabolite concentrations were derived by using multi-voxel analysis based on lobar-level anatomic regions. Results: For whole-brain mean values, the intrasubject COVs were 14%, 15%, and 20% for NAA, tCr, and tCho, respectively, and 31% for Glx and mI. The intersubject COVs were up to 6% higher. For regional distributions, the intrasubject COVs were ≤ 5% for NAA, tCr, and tCho; ≤ 9% for Glx; and ≤15% for mI, with about 6% higher intersubject COVs. The ICCs of 5 metabolites were ≥ 0.7, indicating the reliability of the measurements. Conclusion: The present EPSI method enables estimation of the whole-brain metabolite distributions, including Glx and mI with small voxel size, and a reasonable scan time and reproducibility.

Original languageEnglish (US)
Pages (from-to)921-928
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 1 2015


  • Glutamate
  • Glutamine
  • Myo-inositol
  • Short acquisition time
  • Short TE MRSI
  • Whole-brain MRSI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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