Reproducibility and circadian rhythm of heart rate variability in healthy subjects

Heikki V. Huikuri, Kenneth M. Kessler, Elisabeth Terracall, Agustin Castellanos, Markku K. Linnaluoto, Robert J. Myerburg

Research output: Contribution to journalArticle

160 Scopus citations


Low heart rate (HR) variability, expressed as the standard deviation of cardiac cycle lengths, has been shown to be associated with increased mortality in patients with coronary artery disease.1,2 HR variability can be easily measured from 24-hour electrocardiographic recordings using recently developed software.1,2 However, reference values for HR variability and their reproducibility in normal persons are not well studied. We estimated the reproducibility and circadian rhythm of HR variability, measured from repeated 24-hour electrocardiographic recordings, in young healthy adults to establish normal values and determine patterns of reproducibility.

Original languageEnglish (US)
Pages (from-to)391-393
Number of pages3
JournalThe American Journal of Cardiology
Issue number5
StatePublished - Feb 1 1990


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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