Repressive translational control in germ cells

Fangfang Lai, Mary Lou L King

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The earliest stages of embryonic development in many animals proceed without zygotic transcription. Genetic control is executed by maternally inherited mRNAs that are under translational control. To set aside the future germ cell lineage, it is pivotal to both exert translational regulation of maternal germline mRNAs and to repress maternal signals in those same cells that drive somatic cell-fate determination. Here we review repressive translational regulation in the germline from the perspective of the conserved RNA binding proteins Pumilio and Nanos, and discuss common themes that have emerged.

Original languageEnglish
Pages (from-to)665-676
Number of pages12
JournalMolecular Reproduction and Development
Volume80
Issue number8
DOIs
StatePublished - Aug 1 2013

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Germ Cells
Stored Messenger RNA
RNA-Binding Proteins
Cell Lineage
Embryonic Development
Mothers
Messenger RNA
Maternal Inheritance

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Repressive translational control in germ cells. / Lai, Fangfang; King, Mary Lou L.

In: Molecular Reproduction and Development, Vol. 80, No. 8, 01.08.2013, p. 665-676.

Research output: Contribution to journalArticle

Lai, Fangfang ; King, Mary Lou L. / Repressive translational control in germ cells. In: Molecular Reproduction and Development. 2013 ; Vol. 80, No. 8. pp. 665-676.
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