Reported alcohol consumption and cognitive decline: The Northern Manhattan Study

Clinton B Wright, Mitchell S V Elkind, Xiaodong Luo, Myunghee C. Paik, Ralph L Sacco

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Moderate alcohol intake may slow cognitive decline, and both vascular and neurodegenerative mechanisms have been implicated. Methods: We examined reported alcohol intake and cognitive decline in a community-based cohort of Hispanic, black and white individuals (n = 1,428). The role of the apolipoprotein E ε4 (APOE4) allele as a modifier was also studied. Results and Conclusions: Reported drinking was as follows: 300 participants (21%) were 'never' drinkers, 622 (44%) 'past' drinkers, 145 (10%) reported taking less than 1 drink weekly, 330 (23%) 1 drink weekly up to 2 daily and 31 (2%) more than 2 drinks daily. A positive relationship was seen between reported alcohol intake and cognition. Drinking less than 1 drink a week (p = 0.09), between 1 drink weekly up to 2 drinks daily (p = 0.001) and more than 2 drinks daily (p = 0.003) were associated with less cognitive decline on the modified Telephone Interview for Cognitive Status compared to never drinkers. This dose-response relationship was not modified by the presence of an APOE4 allele in a subsample.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalNeuroepidemiology
Volume27
Issue number4
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Fingerprint

Alcohol Drinking
Apolipoprotein E4
Alcohols
Drinking
Alleles
Hispanic Americans
Cognition
Blood Vessels
Interviews
Cognitive Dysfunction
hydroquinone

Keywords

  • Alcohol drinking
  • Apolipoprotein E4
  • Cognition disorders

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Reported alcohol consumption and cognitive decline : The Northern Manhattan Study. / Wright, Clinton B; Elkind, Mitchell S V; Luo, Xiaodong; Paik, Myunghee C.; Sacco, Ralph L.

In: Neuroepidemiology, Vol. 27, No. 4, 01.12.2006, p. 201-207.

Research output: Contribution to journalArticle

Wright, Clinton B ; Elkind, Mitchell S V ; Luo, Xiaodong ; Paik, Myunghee C. ; Sacco, Ralph L. / Reported alcohol consumption and cognitive decline : The Northern Manhattan Study. In: Neuroepidemiology. 2006 ; Vol. 27, No. 4. pp. 201-207.
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