Report on a patient with paroxysmal cold hemoglobinuria

Pochi Ramalingam Subbarayan; Tsutomu Shichishima; Hiroshi Yoshida; Sachio Maruyama; Masaharu Naiki

doi:10.1016/s0925-5710(96)00548-8

Report on a patient with paroxysmal cold hemoglobinuria

Pochi Ramalingam Subbarayan, Tsutomu Shichishima, Hiroshi Yoshida, Sachio Maruyama, Masaharu Naiki

Medicine

Research output: Contribution to journal › Article

Abstract

Antibodies against the human blood group P antigen (anti-P alloantibodies) agglutinate phenotype P₁ and P₂ erythrocytes treated with papain at 4°C but not phenotype P(K) and p erythrocytes. This condition is referred to as an autoimmune disease of paroxysmal cold hemoglobinuria (PCH), and the anti-P specificity is found in the cold hemagglutinins. Serum from a patient suspected to be suffering from PCH by the cold auto-agglutination properties was tested for anti-P specificity, using papain-treated O blood group erythrocytes. The serum-mediated hemagglutination and the serum and complement-mediated immunohemolysis were inhibited by globoside (P antigen GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide) and Forssman glycosphingolipid (GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide). Therefore, we concluded that she had PCH. She was completely cured 6 months later.

Original language	English (US)
Pages (from-to)	165-167
Number of pages	3
Journal	International journal of hematology
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/s0925-5710(96)00548-8
State	Published - Feb 1997

Keywords

Auto-hemoagglutination
Donath and Landsteiner
P antigen
PCH

ASJC Scopus subject areas

Hematology

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Subbarayan, P. R., Shichishima, T., Yoshida, H., Maruyama, S., & Naiki, M. (1997). Report on a patient with paroxysmal cold hemoglobinuria. International journal of hematology, 65(2), 165-167. https://doi.org/10.1016/s0925-5710(96)00548-8

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abstract = "Antibodies against the human blood group P antigen (anti-P alloantibodies) agglutinate phenotype P1 and P2 erythrocytes treated with papain at 4°C but not phenotype P(K) and p erythrocytes. This condition is referred to as an autoimmune disease of paroxysmal cold hemoglobinuria (PCH), and the anti-P specificity is found in the cold hemagglutinins. Serum from a patient suspected to be suffering from PCH by the cold auto-agglutination properties was tested for anti-P specificity, using papain-treated O blood group erythrocytes. The serum-mediated hemagglutination and the serum and complement-mediated immunohemolysis were inhibited by globoside (P antigen GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide) and Forssman glycosphingolipid (GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide). Therefore, we concluded that she had PCH. She was completely cured 6 months later.",

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AU - Yoshida, Hiroshi

AU - Maruyama, Sachio

AU - Naiki, Masaharu

PY - 1997/2

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N2 - Antibodies against the human blood group P antigen (anti-P alloantibodies) agglutinate phenotype P1 and P2 erythrocytes treated with papain at 4°C but not phenotype P(K) and p erythrocytes. This condition is referred to as an autoimmune disease of paroxysmal cold hemoglobinuria (PCH), and the anti-P specificity is found in the cold hemagglutinins. Serum from a patient suspected to be suffering from PCH by the cold auto-agglutination properties was tested for anti-P specificity, using papain-treated O blood group erythrocytes. The serum-mediated hemagglutination and the serum and complement-mediated immunohemolysis were inhibited by globoside (P antigen GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide) and Forssman glycosphingolipid (GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide). Therefore, we concluded that she had PCH. She was completely cured 6 months later.

AB - Antibodies against the human blood group P antigen (anti-P alloantibodies) agglutinate phenotype P1 and P2 erythrocytes treated with papain at 4°C but not phenotype P(K) and p erythrocytes. This condition is referred to as an autoimmune disease of paroxysmal cold hemoglobinuria (PCH), and the anti-P specificity is found in the cold hemagglutinins. Serum from a patient suspected to be suffering from PCH by the cold auto-agglutination properties was tested for anti-P specificity, using papain-treated O blood group erythrocytes. The serum-mediated hemagglutination and the serum and complement-mediated immunohemolysis were inhibited by globoside (P antigen GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide) and Forssman glycosphingolipid (GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide). Therefore, we concluded that she had PCH. She was completely cured 6 months later.

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