TY - JOUR
T1 - Report on a patient with paroxysmal cold hemoglobinuria
AU - Subbarayan, Pochi Ramalingam
AU - Shichishima, Tsutomu
AU - Yoshida, Hiroshi
AU - Maruyama, Sachio
AU - Naiki, Masaharu
PY - 1997/2
Y1 - 1997/2
N2 - Antibodies against the human blood group P antigen (anti-P alloantibodies) agglutinate phenotype P1 and P2 erythrocytes treated with papain at 4°C but not phenotype P(K) and p erythrocytes. This condition is referred to as an autoimmune disease of paroxysmal cold hemoglobinuria (PCH), and the anti-P specificity is found in the cold hemagglutinins. Serum from a patient suspected to be suffering from PCH by the cold auto-agglutination properties was tested for anti-P specificity, using papain-treated O blood group erythrocytes. The serum-mediated hemagglutination and the serum and complement-mediated immunohemolysis were inhibited by globoside (P antigen GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide) and Forssman glycosphingolipid (GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide). Therefore, we concluded that she had PCH. She was completely cured 6 months later.
AB - Antibodies against the human blood group P antigen (anti-P alloantibodies) agglutinate phenotype P1 and P2 erythrocytes treated with papain at 4°C but not phenotype P(K) and p erythrocytes. This condition is referred to as an autoimmune disease of paroxysmal cold hemoglobinuria (PCH), and the anti-P specificity is found in the cold hemagglutinins. Serum from a patient suspected to be suffering from PCH by the cold auto-agglutination properties was tested for anti-P specificity, using papain-treated O blood group erythrocytes. The serum-mediated hemagglutination and the serum and complement-mediated immunohemolysis were inhibited by globoside (P antigen GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide) and Forssman glycosphingolipid (GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc-ceramide). Therefore, we concluded that she had PCH. She was completely cured 6 months later.
KW - Auto-hemoagglutination
KW - Donath and Landsteiner
KW - P antigen
KW - PCH
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U2 - 10.1016/s0925-5710(96)00548-8
DO - 10.1016/s0925-5710(96)00548-8
M3 - Article
C2 - 9071821
AN - SCOPUS:0031081365
VL - 65
SP - 165
EP - 167
JO - International Journal of Hematology
JF - International Journal of Hematology
SN - 0925-5710
IS - 2
ER -
