Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography

Mengxi Shen, Qiyu Bo, Minlu Song, Xiaoshuang Jiang, Zohar Yehoshua, Giovanni Gregori, Xiaodong Sun, Fenghua Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate the morphological changes of polyps in eyes with polypoidal choroidal vasculopathy (PCV) after treatment with vascular endothelial growth factor (VEGF) inhibitors using swept source optical coherence tomography angiography (SS-OCTA). Observations: Following anti-VEGF therapy, polyps were found to evolve into typical type 1 macular neovascularization (MNV) in five eyes. In all of these five eyes, a polypoidal lesion was detected adjacent to a serous or hemorrhagic retinal pigment epithelial detachment (PED). Conclusions and importance: Polypoidal lesions in PCV can evolve into typical type 1 MNV. This morphological evolution suggests that these polyps are clusters of tangled vessels that can proliferate into a more typical neovascular pattern, and this evolution may be facilitated by being adjacent to a PED. Since this morphological appearance could be associated with a better prognosis, SS-OCTA might be helpful in identifying cases of transformed polyps that may be associated with a decreased risk for vision loss.

Original languageEnglish (US)
Article number101057
JournalAmerican Journal of Ophthalmology Case Reports
Volume22
DOIs
StatePublished - Jun 2021

Keywords

  • Anti-vascular endothelial growth factor treatment
  • Polyp
  • Polypoidal choroidal vasculopathy
  • Swept source OCT angiography
  • Type 1 macular neovascularization

ASJC Scopus subject areas

  • Ophthalmology

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