TY - JOUR
T1 - Replacement of polyps with type 1 macular neovascularization in polypoidal choroidal vasculopathy imaged with swept source OCT angiography
AU - Shen, Mengxi
AU - Bo, Qiyu
AU - Song, Minlu
AU - Jiang, Xiaoshuang
AU - Yehoshua, Zohar
AU - Gregori, Giovanni
AU - Sun, Xiaodong
AU - Wang, Fenghua
AU - Rosenfeld, Philip J.
N1 - Funding Information:
Research supported by grants from Carl Zeiss Meditec, Inc. (Dublin, CA), the Salah Foundation , an unrestricted grant from the Research to Prevent Blindness, Inc. , New York, NY, and the National Eye Institute Center Core Grant ( P30EY014801 ) to the Department of Ophthalmology, University of Miami Miller School of Medicine. The funding organizations had no role in the design or conduct of this research.
Funding Information:
Philip Rosenfeld receives research support from Carl Zeiss Meditec, Inc and Stealth Bio Therapeutics. He is a consultant for Apellis, Biogen, Boehringer-Ingelheim, Carl Zeiss Meditec, Chengdu Kanghong Biotech, EyePoint, Ocunexus Therapeutics, Ocudyne, and Unity Biotechnology. He has equity interests in Apellis, Ocudyne, Valitor, and Verana Health.
Publisher Copyright:
© 2021 The Authors
PY - 2021/6
Y1 - 2021/6
N2 - Purpose: To investigate the morphological changes of polyps in eyes with polypoidal choroidal vasculopathy (PCV) after treatment with vascular endothelial growth factor (VEGF) inhibitors using swept source optical coherence tomography angiography (SS-OCTA). Observations: Following anti-VEGF therapy, polyps were found to evolve into typical type 1 macular neovascularization (MNV) in five eyes. In all of these five eyes, a polypoidal lesion was detected adjacent to a serous or hemorrhagic retinal pigment epithelial detachment (PED). Conclusions and importance: Polypoidal lesions in PCV can evolve into typical type 1 MNV. This morphological evolution suggests that these polyps are clusters of tangled vessels that can proliferate into a more typical neovascular pattern, and this evolution may be facilitated by being adjacent to a PED. Since this morphological appearance could be associated with a better prognosis, SS-OCTA might be helpful in identifying cases of transformed polyps that may be associated with a decreased risk for vision loss.
AB - Purpose: To investigate the morphological changes of polyps in eyes with polypoidal choroidal vasculopathy (PCV) after treatment with vascular endothelial growth factor (VEGF) inhibitors using swept source optical coherence tomography angiography (SS-OCTA). Observations: Following anti-VEGF therapy, polyps were found to evolve into typical type 1 macular neovascularization (MNV) in five eyes. In all of these five eyes, a polypoidal lesion was detected adjacent to a serous or hemorrhagic retinal pigment epithelial detachment (PED). Conclusions and importance: Polypoidal lesions in PCV can evolve into typical type 1 MNV. This morphological evolution suggests that these polyps are clusters of tangled vessels that can proliferate into a more typical neovascular pattern, and this evolution may be facilitated by being adjacent to a PED. Since this morphological appearance could be associated with a better prognosis, SS-OCTA might be helpful in identifying cases of transformed polyps that may be associated with a decreased risk for vision loss.
KW - Anti-vascular endothelial growth factor treatment
KW - Polyp
KW - Polypoidal choroidal vasculopathy
KW - Swept source OCT angiography
KW - Type 1 macular neovascularization
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U2 - 10.1016/j.ajoc.2021.101057
DO - 10.1016/j.ajoc.2021.101057
M3 - Article
AN - SCOPUS:85102582764
VL - 22
JO - American Journal of Ophthalmology Case Reports
JF - American Journal of Ophthalmology Case Reports
SN - 2451-9936
M1 - 101057
ER -