Repercussions of early versus late initiation of dialysis

Luis M. Ortega, Ali Nayer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Despite the widespread use of chronic dialysis, there remains a lack of consensus about the optimal time for initiation of renal replacement therapy. Recommendations from the National Kidney Foundation Kidney Disease Outcome Quality Initiative are generally used as the guideline. This has resulted in a trend in the past decade toward earlier initiation of dialysis, especially in the elderly. The associated burden of comorbidities in the elderly population has resulted in greatly reduced survival outcomes. Here, the data obtained from retrospective cohort studies have been corroborated with a recent randomized control trial conducted in Australia and New Zealand (IDEAL study). There are limitations to consider from the IDEAL study that originate from different confounding factors that intervene in the test population. The present paper is an evidence-based review of the literature, focusing on diminution of survival outcomes following the early initiation of dialysis.

Original languageEnglish
Pages (from-to)392-396
Number of pages5
JournalNefrologia
Volume31
Issue number4
DOIs
StatePublished - Aug 9 2011

Fingerprint

Dialysis
Renal Replacement Therapy
Population Growth
Kidney Diseases
New Zealand
Population
Comorbidity
Cohort Studies
Retrospective Studies
Guidelines
Kidney

Keywords

  • Glomerular filtration rate
  • Hemodialysis
  • Malnutrition
  • Mortality
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Nephrology

Cite this

Repercussions of early versus late initiation of dialysis. / Ortega, Luis M.; Nayer, Ali.

In: Nefrologia, Vol. 31, No. 4, 09.08.2011, p. 392-396.

Research output: Contribution to journalArticle

Ortega, Luis M. ; Nayer, Ali. / Repercussions of early versus late initiation of dialysis. In: Nefrologia. 2011 ; Vol. 31, No. 4. pp. 392-396.
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