Repeated neurotensin administration in the ventral tegmental area: Effects on baseline and d-amphetamine-induced locomotor activity

Peter J. Elliott, Charles B. Nemeroff

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Microinjections of neurotensin (NT) into the ventral tegmental area (VTA) of the rat increases locomotor activity. This effect on locomotion is potentiated by daily infustions of NT; in contrast a different injection schedule, i.e. every 48 h, had no such effect. In addition, daily NT injections in the VTA do not alter the locomotor response to a relatively low dose (0.5 mg/kg) of d-amphetamine. These results provide further evidence that NT can modulate the mesolimbic dopamine pathway.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalNeuroscience Letters
Volume68
Issue number2
DOIs
StatePublished - Jul 24 1986
Externally publishedYes

Keywords

  • amphetamine
  • dopamine
  • locomotor activity
  • neurotensin
  • ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)

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