Repeated neurotensin administration in the ventral tegmental area: Effects on baseline and d-amphetamine-induced locomotor activity

Peter J. Elliott, Charles B. Nemeroff

Research output: Contribution to journalArticle

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Abstract

Microinjections of neurotensin (NT) into the ventral tegmental area (VTA) of the rat increases locomotor activity. This effect on locomotion is potentiated by daily infustions of NT; in contrast a different injection schedule, i.e. every 48 h, had no such effect. In addition, daily NT injections in the VTA do not alter the locomotor response to a relatively low dose (0.5 mg/kg) of d-amphetamine. These results provide further evidence that NT can modulate the mesolimbic dopamine pathway.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalNeuroscience Letters
Volume68
Issue number2
DOIs
StatePublished - Jul 24 1986

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Keywords

  • amphetamine
  • dopamine
  • locomotor activity
  • neurotensin
  • ventral tegmental area

ASJC Scopus subject areas

  • Neuroscience(all)

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