Repeated neurotensin administration in the ventral tegmental area: Effects on baseline and d-amphetamine-induced locomotor activity

Peter J. Elliott; Charles B. Nemeroff

doi:10.1016/0304-3940(86)90149-7

Repeated neurotensin administration in the ventral tegmental area: Effects on baseline and d-amphetamine-induced locomotor activity

Peter J. Elliott, Charles B. Nemeroff

Research output: Contribution to journal › Article

59 Scopus citations

Abstract

Microinjections of neurotensin (NT) into the ventral tegmental area (VTA) of the rat increases locomotor activity. This effect on locomotion is potentiated by daily infustions of NT; in contrast a different injection schedule, i.e. every 48 h, had no such effect. In addition, daily NT injections in the VTA do not alter the locomotor response to a relatively low dose (0.5 mg/kg) of d-amphetamine. These results provide further evidence that NT can modulate the mesolimbic dopamine pathway.

Original language	English (US)
Pages (from-to)	239-244
Number of pages	6
Journal	Neuroscience Letters
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(86)90149-7
State	Published - Jul 24 1986
Externally published	Yes

Keywords

amphetamine
dopamine
locomotor activity
neurotensin
ventral tegmental area

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(86)90149-7

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Elliott, P. J., & Nemeroff, C. B. (1986). Repeated neurotensin administration in the ventral tegmental area: Effects on baseline and d-amphetamine-induced locomotor activity. Neuroscience Letters, 68(2), 239-244. https://doi.org/10.1016/0304-3940(86)90149-7

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