Abstract
Microinjections of neurotensin (NT) into the ventral tegmental area (VTA) of the rat increases locomotor activity. This effect on locomotion is potentiated by daily infustions of NT; in contrast a different injection schedule, i.e. every 48 h, had no such effect. In addition, daily NT injections in the VTA do not alter the locomotor response to a relatively low dose (0.5 mg/kg) of d-amphetamine. These results provide further evidence that NT can modulate the mesolimbic dopamine pathway.
Original language | English (US) |
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Pages (from-to) | 239-244 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 68 |
Issue number | 2 |
DOIs | |
State | Published - Jul 24 1986 |
Externally published | Yes |
Keywords
- amphetamine
- dopamine
- locomotor activity
- neurotensin
- ventral tegmental area
ASJC Scopus subject areas
- Neuroscience(all)