Repeated methamphetamine-treatment alters brain δ receptors

Yossef Itzhak

doi:10.1016/0014-2999(93)90810-5

Repeated methamphetamine-treatment alters brain δ receptors

Yossef Itzhak

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in σ receptor binding. A significant up-regulation (130-145% of control B_max) of σ receptors, labeled with [³H](+)pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of σ receptors in critical brain regions.

Original language	English (US)
Pages (from-to)	243-244
Number of pages	2
Journal	European Journal of Pharmacology
Volume	230
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(93)90810-5
State	Published - Jan 12 1993

Keywords

Methamphetamine
Psychosis
σ Receptors

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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title = "Repeated methamphetamine-treatment alters brain δ receptors",

abstract = "The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in σ receptor binding. A significant up-regulation (130-145% of control Bmax) of σ receptors, labeled with [3H](+)pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of σ receptors in critical brain regions.",

keywords = "Methamphetamine, Psychosis, σ Receptors",

author = "Yossef Itzhak",

note = "Funding Information: This work was supported by research grants from the National Institute on Drug Abuse (DA-07589) and the National Alliance for the Mentally I11, the Theodore and Vada Stanley Foundation.",

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PY - 1993/1/12

Y1 - 1993/1/12

N2 - The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in σ receptor binding. A significant up-regulation (130-145% of control Bmax) of σ receptors, labeled with [3H](+)pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of σ receptors in critical brain regions.

AB - The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in σ receptor binding. A significant up-regulation (130-145% of control Bmax) of σ receptors, labeled with [3H](+)pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of σ receptors in critical brain regions.

KW - Methamphetamine

KW - Psychosis

KW - σ Receptors

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Repeated methamphetamine-treatment alters brain δ receptors

Abstract

Keywords

ASJC Scopus subject areas

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