Repeated methamphetamine-treatment alters brain δ receptors

Yossef Itzhak

doi:10.1016/0014-2999(93)90810-5

Repeated methamphetamine-treatment alters brain δ receptors

Yossef Itzhak

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article

37 Scopus citations

Abstract

The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in σ receptor binding. A significant up-regulation (130-145% of control B_max) of σ receptors, labeled with [³H](+)pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of σ receptors in critical brain regions.

Original language	English (US)
Pages (from-to)	243-244
Number of pages	2
Journal	European Journal of Pharmacology
Volume	230
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(93)90810-5
State	Published - Jan 12 1993

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Keywords

Methamphetamine
Psychosis
σ Receptors

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

Cite this

Itzhak, Y. (1993). Repeated methamphetamine-treatment alters brain δ receptors. European Journal of Pharmacology, 230(2), 243-244. https://doi.org/10.1016/0014-2999(93)90810-5

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10.1016/0014-2999(93)90810-5