Repeated methamphetamine-treatment alters brain δ receptors

Yossef Itzhak

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in σ receptor binding. A significant up-regulation (130-145% of control Bmax) of σ receptors, labeled with [3H](+)pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of σ receptors in critical brain regions.

Original languageEnglish (US)
Pages (from-to)243-244
Number of pages2
JournalEuropean Journal of Pharmacology
Issue number2
StatePublished - Jan 12 1993


  • Methamphetamine
  • Psychosis
  • σ Receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology


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