Abstract
The present study was undertaken to examine whether repeated exposure of rats to the psychostimulant drug, methamphetamine, induces changes in σ receptor binding. A significant up-regulation (130-145% of control Bmax) of σ receptors, labeled with [3H](+)pentazocine, was observed in the substantia nigra, frontal cortex and cerebellum of rats treated with methamphetamine (4.0 mg/kg per day; 10 days). These findings suggest that methamphetamine-induced psychosis may be associated with the up-regulation of σ receptors in critical brain regions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-244 |
| Number of pages | 2 |
| Journal | European Journal of Pharmacology |
| Volume | 230 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 12 1993 |
Keywords
- Methamphetamine
- Psychosis
- σ Receptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Itzhak, Y. (1993). Repeated methamphetamine-treatment alters brain δ receptors. European Journal of Pharmacology, 230(2), 243-244. https://doi.org/10.1016/0014-2999(93)90810-5