Repeated denervation and reinnervation of skeletal muscle

Walter G Bradley, T. A. Papapetropoulos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

THE skeletal muscle in human muscular dystrophy shows marked degenerative changes while the central and peripheral nervous systems usually show no abnormality, apart from cerebral malformation underlying co-existing mental deficiency1-3. In the late stages, there may be some loss of anterior horn cells in the spinal cord4. On the basis of these pathological findings, muscular dystrophy has always been considered to be a primary muscle disease. An inherited abnormality of the Bar Harbor 129 strain of mice shows similar pathological changes in the skeletal muscle and no central nervous system abnormality5,6. Motor end plates are infrequent on the small atrophic fibres of the muscles, however7, and electromyography in these animals shows fibrillation potentials and high frequency discharges similar to those seen in human dystrophia myotonica and denervation8. Other findings suggestive of denervation are the reduction of frequency of miniature end plate potentials9, and the supersensitivity of the muscle to neostigmine and insensitivity to d-tubocurarine10. McComas and Mrozek11 found direct evidence of a proportion of denervated fibres in murine muscular dystrophy.

Original languageEnglish
Pages (from-to)401-402
Number of pages2
JournalNature
Volume236
Issue number5347
DOIs
StatePublished - Dec 1 1972
Externally publishedYes

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Muscular Dystrophies
Denervation
129 Strain Mouse
Skeletal Muscle
Muscles
Central Nervous System
Motor Endplate
Anterior Horn Cells
Neostigmine
Myotonic Dystrophy
Peripheral Nervous System
Electromyography

ASJC Scopus subject areas

  • General

Cite this

Repeated denervation and reinnervation of skeletal muscle. / Bradley, Walter G; Papapetropoulos, T. A.

In: Nature, Vol. 236, No. 5347, 01.12.1972, p. 401-402.

Research output: Contribution to journalArticle

Bradley, Walter G ; Papapetropoulos, T. A. / Repeated denervation and reinnervation of skeletal muscle. In: Nature. 1972 ; Vol. 236, No. 5347. pp. 401-402.
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