Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies

Thomas J. Povsic, Ricardo Sanz-Ruiz, Andreu M. Climent, Roberto Bolli, Doris A. Taylor, Bernard J. Gersh, Philippe Menasché, Emerson C. Perin, Giulio Pompilio, Douwe E. Atsma, Lina Badimon, Anthony N. DeMaria, Joshua M. Hare, Timothy D. Henry, Stefan Janssens, Jens Kastrup, Daniele Torella, Jay H. Traverse, James T. Willerson, Francisco Fernández-Avilés

Research output: Contribution to journalArticlepeer-review

Abstract

The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, determine what can be learned from past mistakes, and formulate best practices for future work. This special communication summarizes an introspective assessment of what has fallen short, how to prevent similar issues, and how the field might best move forward in the service of science and patients.

Original languageEnglish (US)
JournalESC Heart Failure
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Keywords

  • Myocardial repair and regeneration
  • Reparative cell therapy
  • Stem cell therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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