Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies

Thomas J. Povsic; Ricardo Sanz-Ruiz; Andreu M. Climent; Roberto Bolli; Doris A. Taylor; Bernard J. Gersh; Philippe Menasché; Emerson C. Perin; Giulio Pompilio; Douwe E. Atsma; Lina Badimon; Anthony N. DeMaria; Joshua M. Hare; Timothy D. Henry; Stefan Janssens; Jens Kastrup; Daniele Torella; Jay H. Traverse; James T. Willerson; Francisco Fernández-Avilés

doi:10.1002/ehf2.13256

Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies

Thomas J. Povsic, Ricardo Sanz-Ruiz, Andreu M. Climent, Roberto Bolli, Doris A. Taylor, Bernard J. Gersh, Philippe Menasché, Emerson C. Perin, Giulio Pompilio, Douwe E. Atsma, Lina Badimon, Anthony N. DeMaria, Joshua M. Hare, Timothy D. Henry, Stefan Janssens, Jens Kastrup, Daniele Torella, Jay H. Traverse, James T. Willerson, Francisco Fernández-Avilés

Research output: Contribution to journal › Article › peer-review

Abstract

The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, determine what can be learned from past mistakes, and formulate best practices for future work. This special communication summarizes an introspective assessment of what has fallen short, how to prevent similar issues, and how the field might best move forward in the service of science and patients.

Original language	English (US)
Journal	ESC Heart Failure
DOIs	https://doi.org/10.1002/ehf2.13256
State	Accepted/In press - 2021
Externally published	Yes

Keywords

Myocardial repair and regeneration
Reparative cell therapy
Stem cell therapy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1002/ehf2.13256

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Povsic, T. J., Sanz-Ruiz, R., Climent, A. M., Bolli, R., Taylor, D. A., Gersh, B. J., Menasché, P., Perin, E. C., Pompilio, G., Atsma, D. E., Badimon, L., DeMaria, A. N., Hare, J. M., Henry, T. D., Janssens, S., Kastrup, J., Torella, D., Traverse, J. H., Willerson, J. T., & Fernández-Avilés, F. (Accepted/In press). Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. ESC Heart Failure. https://doi.org/10.1002/ehf2.13256

Reparative cell therapy for the heart : critical internal appraisal of the field in response to recent controversies. / Povsic, Thomas J.; Sanz-Ruiz, Ricardo; Climent, Andreu M.; Bolli, Roberto; Taylor, Doris A.; Gersh, Bernard J.; Menasché, Philippe; Perin, Emerson C.; Pompilio, Giulio; Atsma, Douwe E.; Badimon, Lina; DeMaria, Anthony N.; Hare, Joshua M.; Henry, Timothy D.; Janssens, Stefan; Kastrup, Jens; Torella, Daniele; Traverse, Jay H.; Willerson, James T.; Fernández-Avilés, Francisco.

In: ESC Heart Failure, 2021.

Research output: Contribution to journal › Article › peer-review

Povsic, TJ, Sanz-Ruiz, R, Climent, AM, Bolli, R, Taylor, DA, Gersh, BJ, Menasché, P, Perin, EC, Pompilio, G, Atsma, DE, Badimon, L, DeMaria, AN, Hare, JM, Henry, TD, Janssens, S, Kastrup, J, Torella, D, Traverse, JH, Willerson, JT & Fernández-Avilés, F 2021, 'Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies', ESC Heart Failure. https://doi.org/10.1002/ehf2.13256

Povsic, Thomas J. ; Sanz-Ruiz, Ricardo ; Climent, Andreu M. ; Bolli, Roberto ; Taylor, Doris A. ; Gersh, Bernard J. ; Menasché, Philippe ; Perin, Emerson C. ; Pompilio, Giulio ; Atsma, Douwe E. ; Badimon, Lina ; DeMaria, Anthony N. ; Hare, Joshua M. ; Henry, Timothy D. ; Janssens, Stefan ; Kastrup, Jens ; Torella, Daniele ; Traverse, Jay H. ; Willerson, James T. ; Fernández-Avilés, Francisco. / Reparative cell therapy for the heart : critical internal appraisal of the field in response to recent controversies. In: ESC Heart Failure. 2021.

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abstract = "The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, determine what can be learned from past mistakes, and formulate best practices for future work. This special communication summarizes an introspective assessment of what has fallen short, how to prevent similar issues, and how the field might best move forward in the service of science and patients.",

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AU - DeMaria, Anthony N.

AU - Hare, Joshua M.

AU - Henry, Timothy D.

AU - Janssens, Stefan

AU - Kastrup, Jens

AU - Torella, Daniele

AU - Traverse, Jay H.

AU - Willerson, James T.

AU - Fernández-Avilés, Francisco

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Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies

Abstract

Keywords

ASJC Scopus subject areas

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