Repair of traumatized mammalian hair cells via sea anemone repair proteins

Pei Ciao Tang, Karen Müller Smith, Glen M. Watson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Mammalian hair cells possess only a limited ability to repair damage after trauma. In contrast, sea anemones show a marked capability to repair damaged hair bundles by means of secreted repair proteins (RPs). Previously, it was found that recovery of traumatized hair cells in blind cavefish was enhanced by anemone-derived RPs; therefore, the ability of anemone RPs to assist recovery of damaged hair cells in mammals was tested here. After a 1 h incubation in RP-enriched culture media, uptake of FM1-43 by experimentally traumatized murine cochlear hair cells was restored to levels comparable to those exhibited by healthy controls. In addition, RP-treated explants had significantly more normally structured hair bundles than timematched traumatized control explants. Collectively, these results indicate that anemone-derived RPs assist in restoring normal function and structure of experimentally traumatized hair cells of the mouse cochlea.

Original languageEnglish (US)
Pages (from-to)2265-2270
Number of pages6
JournalJournal of Experimental Biology
Volume219
Issue number15
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Keywords

  • Cochlea
  • Deafness
  • Hair cell evolution
  • Mouse
  • Outer hair cells

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

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