Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice

J. Denise Wetzel, Erik S. Barton, James D. Chappell, Geoffrey S. Baer, Michelle Mochow-Grundy, Steven E. Rodgers, Yu Shyr, Alvin C. Powers, James W. Thomas, Terence S. Dermody

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Mice infected with reovirus develop abnormalities in glucose homeostasis. Reovirus strain type 3 Abney (T3A) was capable of systemic infection of nonobese diabetic (NOD) mice, an experimental model of autoimmune diabetes. Reovirus antigen was detected in pancreatic islets of T3A-infected mice, and primary cultures of pancreatic islets from NOD mice supported T3A growth. Significantly fewer T3A-infected animals compared to uninfected controls developed diabetes. However, despite the alteration in diabetes penetrance, insulitis was evident in T3A-infected mice. These results suggest that viral infection of NOD mice alters autoimmune responses to β-cell antigens and thereby delays development of diabetes.

Original languageEnglish (US)
Pages (from-to)3078-3082
Number of pages5
JournalJournal of virology
Volume80
Issue number6
DOIs
StatePublished - Mar 2006

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Wetzel, J. D., Barton, E. S., Chappell, J. D., Baer, G. S., Mochow-Grundy, M., Rodgers, S. E., Shyr, Y., Powers, A. C., Thomas, J. W., & Dermody, T. S. (2006). Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. Journal of virology, 80(6), 3078-3082. https://doi.org/10.1128/JVI.80.6.3078-3082.2006