Reoperation for acute hemispheric stroke after carotid endarterectomy

Is there any value?

J. Max Findlay, B. Elaine Marchak, G. Michael Lemole, Jeffrey S. Henn, Robert F. Spetzler, Christopher S. Ogilvy, Roberto Heros

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: Because the clinical benefit of urgent investigation and carotid rerepair for acute stroke complicating carotid endarterectomy (CEA) is uncertain, the results of this approach were examined in a large series of patients. METHODS: In a consecutive series of 700 CEAs, 24 patients (3.4%) had a postoperative stroke. Thirteen of these 24 patients experienced major hemispheric deficits (hemiplegia with or without aphasia, forced eye deviation, and decreased consciousness) that prompted either immediate surgical reexploration or cerebral angiography with reoperation on the basis of angiogram results; these 13 patients are the subject of this report. Neurological improvement was attributed to carotid reopening when affected muscle strength increased to antigravity power within 6 hours of reoperation. RESULTS: Of the 13 patients with severe postoperative deficits, 5 (38%) had the deficits when they awakened, 7 deficits occurred within 12 hours of surgery, and the only intracerebral hemorrhage in this series occurred 8 days after surgery. Five patients underwent urgent reoperation without angiography, and carotid occlusions were found and repaired in two patients. In another patient, the carotid was patent, and an intra-arterial injection of tissue plasminogen activator (20 mg) was given. In the seven patients who underwent cerebral angiography as the first step, two carotid occlusions and one residual stenosis with thrombus were found and repaired on an urgent basis. Surgical reopening of occluded arteries was followed by improvement in two of four patients, and early improvement was noted in one patient with a stenosis correction as well as in the patient who received intraoperative tissue plasminogen activator. Four patients who underwent urgent reoperation did not demonstrate a benefit soon after surgery. Two patients died, two were left with major deficits and five with moderate deficits, and four patients eventually had good recovery at a minimum of 6 months of follow-up. CONCLUSION: In this series, approximately one-half of hemispheric strokes complicating CEA had an underlying correctable lesion (occlusion or stenosis), and these patients typically had delayed-onset strokes. Approximately one-half of these patients improved early as a result of reopening, although computed tomography revealed new infarcts in most of them. Urgent carotid repair may benefit a minority of selected patients who have a major stroke after CEA.

Original languageEnglish
Pages (from-to)486-493
Number of pages8
JournalNeurosurgery
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2002
Externally publishedYes

Fingerprint

Carotid Endarterectomy
Reoperation
Stroke
Cerebral Angiography
Pathologic Constriction
Tissue Plasminogen Activator
Angiography
Intra-Arterial Injections
Hemiplegia
Aphasia
Cerebral Hemorrhage
Muscle Strength

Keywords

  • Carotid artery
  • Carotid endarterectomy
  • Complication
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Findlay, J. M., Marchak, B. E., Lemole, G. M., Henn, J. S., Spetzler, R. F., Ogilvy, C. S., & Heros, R. (2002). Reoperation for acute hemispheric stroke after carotid endarterectomy: Is there any value? Neurosurgery, 50(3), 486-493. https://doi.org/10.1097/00006123-200203000-00010

Reoperation for acute hemispheric stroke after carotid endarterectomy : Is there any value? / Findlay, J. Max; Marchak, B. Elaine; Lemole, G. Michael; Henn, Jeffrey S.; Spetzler, Robert F.; Ogilvy, Christopher S.; Heros, Roberto.

In: Neurosurgery, Vol. 50, No. 3, 01.03.2002, p. 486-493.

Research output: Contribution to journalArticle

Findlay, JM, Marchak, BE, Lemole, GM, Henn, JS, Spetzler, RF, Ogilvy, CS & Heros, R 2002, 'Reoperation for acute hemispheric stroke after carotid endarterectomy: Is there any value?', Neurosurgery, vol. 50, no. 3, pp. 486-493. https://doi.org/10.1097/00006123-200203000-00010
Findlay JM, Marchak BE, Lemole GM, Henn JS, Spetzler RF, Ogilvy CS et al. Reoperation for acute hemispheric stroke after carotid endarterectomy: Is there any value? Neurosurgery. 2002 Mar 1;50(3):486-493. https://doi.org/10.1097/00006123-200203000-00010
Findlay, J. Max ; Marchak, B. Elaine ; Lemole, G. Michael ; Henn, Jeffrey S. ; Spetzler, Robert F. ; Ogilvy, Christopher S. ; Heros, Roberto. / Reoperation for acute hemispheric stroke after carotid endarterectomy : Is there any value?. In: Neurosurgery. 2002 ; Vol. 50, No. 3. pp. 486-493.
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AU - Ogilvy, Christopher S.

AU - Heros, Roberto

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N2 - OBJECTIVE: Because the clinical benefit of urgent investigation and carotid rerepair for acute stroke complicating carotid endarterectomy (CEA) is uncertain, the results of this approach were examined in a large series of patients. METHODS: In a consecutive series of 700 CEAs, 24 patients (3.4%) had a postoperative stroke. Thirteen of these 24 patients experienced major hemispheric deficits (hemiplegia with or without aphasia, forced eye deviation, and decreased consciousness) that prompted either immediate surgical reexploration or cerebral angiography with reoperation on the basis of angiogram results; these 13 patients are the subject of this report. Neurological improvement was attributed to carotid reopening when affected muscle strength increased to antigravity power within 6 hours of reoperation. RESULTS: Of the 13 patients with severe postoperative deficits, 5 (38%) had the deficits when they awakened, 7 deficits occurred within 12 hours of surgery, and the only intracerebral hemorrhage in this series occurred 8 days after surgery. Five patients underwent urgent reoperation without angiography, and carotid occlusions were found and repaired in two patients. In another patient, the carotid was patent, and an intra-arterial injection of tissue plasminogen activator (20 mg) was given. In the seven patients who underwent cerebral angiography as the first step, two carotid occlusions and one residual stenosis with thrombus were found and repaired on an urgent basis. Surgical reopening of occluded arteries was followed by improvement in two of four patients, and early improvement was noted in one patient with a stenosis correction as well as in the patient who received intraoperative tissue plasminogen activator. Four patients who underwent urgent reoperation did not demonstrate a benefit soon after surgery. Two patients died, two were left with major deficits and five with moderate deficits, and four patients eventually had good recovery at a minimum of 6 months of follow-up. CONCLUSION: In this series, approximately one-half of hemispheric strokes complicating CEA had an underlying correctable lesion (occlusion or stenosis), and these patients typically had delayed-onset strokes. Approximately one-half of these patients improved early as a result of reopening, although computed tomography revealed new infarcts in most of them. Urgent carotid repair may benefit a minority of selected patients who have a major stroke after CEA.

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