Renin-angiotensin system blockade and diabetes

Moving the adipose organ from the periphery to the center

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

Original languageEnglish
Pages (from-to)851-853
Number of pages3
JournalKidney International
Volume74
Issue number7
DOIs
StatePublished - Oct 1 2008

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Renin-Angiotensin System
Adipose Tissue
Inbred OLETF Rats
Angiotensin II Type 1 Receptor Blockers
Glucose Intolerance
Chemokine CCL2
Adiponectin
Plasminogen Activator Inhibitor 1
Adipocytes
Type 2 Diabetes Mellitus
Insulin Resistance
Theoretical Models

ASJC Scopus subject areas

  • Nephrology

Cite this

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abstract = "Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.",
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