Abstract
Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.
Original language | English (US) |
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Pages (from-to) | 851-853 |
Number of pages | 3 |
Journal | Kidney international |
Volume | 74 |
Issue number | 7 |
DOIs |
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State | Published - Oct 2008 |
ASJC Scopus subject areas
- Nephrology