Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Oliver Lenz; Alessia Fornoni

doi:10.1038/ki.2008.391

Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Oliver Lenz, Alessia Fornoni

Medicine

Research output: Contribution to journal › Comment/debate

9 Scopus citations

Abstract

Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

Original language	English (US)
Pages (from-to)	851-853
Number of pages	3
Journal	Kidney international
Volume	74
Issue number	7
DOIs	https://doi.org/10.1038/ki.2008.391
State	Published - Oct 2008

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ASJC Scopus subject areas

Nephrology

Cite this

Lenz, O., & Fornoni, A. (2008). Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center. Kidney international, 74(7), 851-853. https://doi.org/10.1038/ki.2008.391

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10.1038/ki.2008.391