Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Oliver Lenz; Alessia Fornoni

doi:10.1038/ki.2008.391

Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Oliver Lenz, Alessia Fornoni

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

Original language	English (US)
Pages (from-to)	851-853
Number of pages	3
Journal	Kidney international
Volume	74
Issue number	7
DOIs	https://doi.org/10.1038/ki.2008.391
State	Published - Oct 2008

ASJC Scopus subject areas

Nephrology

Access to Document

10.1038/ki.2008.391

Fingerprint Dive into the research topics of 'Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center'. Together they form a unique fingerprint.

Cite this

@article{e2fe174dd97b4b8eba4ebd9d252fbc65,

title = "Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center",

abstract = "Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.",

author = "Oliver Lenz and Alessia Fornoni",

note = "Funding Information: This work was supported by the Amgen Junior Faculty Award to Alessia Fornoni, the Katz Family Foundation, and the Diabetes Research Institute Foundation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2008",

month = oct,

doi = "10.1038/ki.2008.391",

language = "English (US)",

volume = "74",

pages = "851--853",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Renin-angiotensin system blockade and diabetes

T2 - Moving the adipose organ from the periphery to the center

AU - Lenz, Oliver

AU - Fornoni, Alessia

N1 - Funding Information: This work was supported by the Amgen Junior Faculty Award to Alessia Fornoni, the Katz Family Foundation, and the Diabetes Research Institute Foundation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2008/10

Y1 - 2008/10

N2 - Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

AB - Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

UR - http://www.scopus.com/inward/record.url?scp=51849158818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51849158818&partnerID=8YFLogxK

U2 - 10.1038/ki.2008.391

DO - 10.1038/ki.2008.391

M3 - Comment/debate

C2 - 18794817

AN - SCOPUS:51849158818

VL - 74

SP - 851

EP - 853

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 7

ER -

Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this