Abstract
Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 851-853 |
| Number of pages | 3 |
| Journal | Kidney International |
| Volume | 74 |
| Issue number | 7 |
| DOIs | |
| State | Published - Oct 1 2008 |
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ASJC Scopus subject areas
- Nephrology
Cite this
Renin-angiotensin system blockade and diabetes : Moving the adipose organ from the periphery to the center. / Lenz, Oliver; Fornoni, Alessia.
In: Kidney International, Vol. 74, No. 7, 01.10.2008, p. 851-853.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Renin-angiotensin system blockade and diabetes
T2 - Moving the adipose organ from the periphery to the center
AU - Lenz, Oliver
AU - Fornoni, Alessia
PY - 2008/10/1
Y1 - 2008/10/1
N2 - Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.
AB - Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.
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U2 - 10.1038/ki.2008.391
DO - 10.1038/ki.2008.391
M3 - Article
C2 - 18794817
AN - SCOPUS:51849158818
VL - 74
SP - 851
EP - 853
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 7
ER -