Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

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Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

Original languageEnglish (US)
Pages (from-to)851-853
Number of pages3
JournalKidney international
Issue number7
StatePublished - Oct 2008


ASJC Scopus subject areas

  • Nephrology

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