Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Oliver Lenz; Alessia Fornoni

doi:10.1038/ki.2008.391

Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Oliver Lenz, Alessia Fornoni

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

Original language	English (US)
Pages (from-to)	851-853
Number of pages	3
Journal	Kidney international
Volume	74
Issue number	7
DOIs	https://doi.org/10.1038/ki.2008.391
State	Published - Oct 2008

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2008.391

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title = "Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center",

abstract = "Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.",

author = "Oliver Lenz and Alessia Fornoni",

note = "Funding Information: This work was supported by the Amgen Junior Faculty Award to Alessia Fornoni, the Katz Family Foundation, and the Diabetes Research Institute Foundation.",

year = "2008",

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doi = "10.1038/ki.2008.391",

language = "English (US)",

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AU - Fornoni, Alessia

N1 - Funding Information: This work was supported by the Amgen Junior Faculty Award to Alessia Fornoni, the Katz Family Foundation, and the Diabetes Research Institute Foundation.

PY - 2008/10

Y1 - 2008/10

N2 - Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

AB - Lee et al. report that an angiotensin II type 1 receptor blocker (ARB) improved glucose intolerance in OLETF rats, an experimental model of type 2 diabetes. ARB treatment resulted in modulation of the adipose tissue, leading to an increased number of small, differentiated adipocytes able to produce more adiponectin and less monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1. This supports the relevance of the functional interplay between adipose tissue and the renin-angiotensin system in states of insulin resistance.

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Renin-angiotensin system blockade and diabetes: Moving the adipose organ from the periphery to the center

Abstract

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