Renal System

Joao Paulo Zambon, Prafulla Chandra, Anthony Atala, James J. Yoo

Research output: Chapter in Book/Report/Conference proceedingChapter


In the United States, approximately 1. million patients live with end-stage renal disease (ESRD), with more than 100,000 new diagnoses every year. Although hemodialysis has increased the survival of patients with ESRD, transplantation remains the only curative treatment currently. However, kidney transplantation is severely limited by shortage of kidney donors, complications due to chronic immunosuppressive therapy posttransplantation and long-term graft failure. These limitations have led researchers to search for alternative therapeutic modalities that could improve, restore, or replace either partial or total renal function. In this context, tissue engineering and regenerative medicine presents with viable approaches to develop new and innovative therapies for renal failure. This chapter describes an overview of new developments related to kidney tissue regeneration.

Original languageEnglish (US)
Title of host publicationTranslational Regenerative Medicine
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780124104570
ISBN (Print)9780124103962
StatePublished - 2015


  • Cell therapy
  • Kidney regeneration
  • Renal failure
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine(all)


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